- Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639
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The discovery of a novel peripherally acting and selective Cav3.2 T-type calcium channel blocker, ABT-639, is described. HTS hits 1 and 2, which have poor metabolic stability, were optimized to obtain 4, which has improved stability and oral bi
- Zhang, Qingwei,Xia, Zhiren,Joshi, Shailen,Scott, Victoria E.,Jarvis, Michael F.
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supporting information
p. 641 - 644
(2015/06/30)
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- NOVEL BENZENESULFONAMIDES AS CALCIUM CHANNEL BLOCKERS
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The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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Page/Page column 61-62
(2010/08/08)
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