123594-01-4

Basic information

• Product Name: 8-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• Synonyms: 8-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE;Isoquinoline,8-fluoro-1,2,3,4-tetrahydro-
• CAS NO: 123594-01-4
• Molecular Formula: C9H10FN
• Molecular Weight: 151.18
• Mol File: 123594-01-4.mol

Chemical Properties

• Boiling Point: 234.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.107
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.82±0.20(Predicted)
• CAS DataBase Reference: 8-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(123594-01-4)
• EPA Substance Registry System: 8-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(123594-01-4)

Safety Data

• Hazardous Substances Data: 123594-01-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
8-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE is used as a key intermediate in the synthesis of biologically active molecules for the development of new pharmaceuticals. Its unique structure and fluorine substitution make it an interesting target for chemical modification, allowing for the exploration of its potential biological activities and the enhancement of drug properties such as potency, selectivity, and metabolic stability.
Used in Drug Research:
In drug research, 8-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE is utilized as a starting material or building block for the design and synthesis of novel drug candidates. Its incorporation into molecular frameworks can lead to the discovery of new therapeutic agents with improved pharmacological profiles, including increased efficacy, reduced side effects, and better pharmacokinetic properties.
Overall, 8-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE plays a crucial role in the advancement of medicinal chemistry and drug discovery, offering a versatile platform for the development of innovative therapeutic agents with potential applications across various medical fields.

Upstream product

• 446-52-6 2-Fluorobenzaldehyde 
• 1075-00-9 8-fluoroisoquinoline 

Relevant articles and documents

Synthesis of 8-fluoro-3,4-dihydroisoquinoline and its transformation to 1,8-disubstituted tetrahydroisoquinolines

A simple procedure for the synthesis of 8-fluoro-3,4-dihydroisoquinoline is described below, based on a directed ortho-lithiation reaction. This key intermediate was then applied in various transformations. Fluorine–amine exchange afforded the corresponding 8-amino-3,4-dihydroisoquinolines, suitable starting compounds for the synthesis of 1-substituted 8-amino-tetrahydroisoquinolines. On the other hand, reduction and alkylation reactions of 8-fluoro-3,4-dihydroisoquinoline led to novel 1,2,3,4-tetrahydroisoquinoline derivatives that can be used as building blocks in the synthesis of potential central nervous system drug candidates.

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.