123594-04-7

Basic information

• Product Name: 4-CHLOROISOINDOLINE
• Synonyms: 4-CHLOROISOINDOLINE;1H-Isoindole,4-chloro-2,3-dihydro-)
• CAS NO: 123594-04-7
• Molecular Formula: C₈H₈ClN
• Molecular Weight: 153.61
• Mol File: 123594-04-7.mol

Chemical Properties

• Boiling Point: 246.6°C at 760 mmHg
• Flash Point: 102.9°C
• Appearance: /
• Density: 1.214g/cm³
• Vapor Pressure: 0.0269mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• PKA: 8.11±0.20(Predicted)
• CAS DataBase Reference: 4-CHLOROISOINDOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROISOINDOLINE(123594-04-7)
• EPA Substance Registry System: 4-CHLOROISOINDOLINE(123594-04-7)

Safety Data

• Hazardous Substances Data: 123594-04-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloroisoindoline is used as a building block for the synthesis of drug molecules, leveraging its unique structural properties to contribute to the development of new pharmaceuticals.
Used in Organic Synthesis:
In the realm of organic synthesis, 4-Chloroisoindoline serves as a versatile intermediate, facilitating the preparation of bioactive molecules that can be further utilized in medicinal chemistry.
Used in Medicinal Chemistry:
4-Chloroisoindoline is employed as a reagent in medicinal chemistry, where it aids in the creation of compounds with potential therapeutic applications, capitalizing on its interesting biological activities.

InChI:InChI=1/C8H8ClN/c9-8-3-1-2-6-4-10-5-7(6)8/h1-3,10H,4-5H2

Upstream product

• 51108-30-6 4-chloro-1H-isoindole-1,3(2H)-dione 
• 7147-90-2 4-chlorophthalimide 

Relevant articles and documents

HCV NS3 protease inhibitors

The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

Isoindoline derivative

Isoindoline derivatives represented by the formula (I) and their salts are disclosed. STR1 There are many varieties for the compound depending on the types of residues R1 -R9 and X. The compounds can be prepared from quinoline derivatives of the formula (II) and an isoindoline derivatives of the formula (III). The compounds of formula (I) and their salts have excellent antibacterial activities against both gram positive and gram negative microorganisms. They can be used as a medicine, an agrichemical, and a food preservative.

Affinity of 2-(tetrahydroisoquinolin-2-methyl)- and 2-(isoindolin-2-ylmethyl)imidazolines for α-adrenoceptors. Differential affinity of imidazolines for the [3H]idazoxan-labeled α2-adrenoceptor vs the [3H]yohimbine-labeled site

A series of 2-(tetrahydroisoquinolin-2-ylmethyl)- and 2-(isoindolin-2-ylmethyl)imidazolines were prepared and tested for α1- and α2-adrenoceptor affinity with radioligand binding. Several compounds, 5-fluoro- (5h), 5-chloro- (5j), 5,8-dimethoxy- (5r), and 5,8-dimethoxy-1-methyl- (5s) 2-(tetrahydroisoquinolin-2-ylmethyl)imidazoline, were found to be selective α2-adrenoceptor ligands on the basis of displacement of [3H]yohimbine from rat cerebral cortical membranes. One compound, 2-[(8-chloro tetrahydroisoquinolin-2-yl)methyl]imidazoline (5m), showed a 36-fold difference in affinity for the [3H]idazoxan-labeled α2-adrenoceptor relative to the [3H]yohimbine-labeled site, which may be evidence for α2-adrenoceptor subtypes.