Expedited Baeyer-Villiger oxidation of steroidal ketones by microwave irradiation
Microwave (MW) assisted reactions are currently having considerable importance in the synthesis of organic compounds. Considering the remarkable application of Baeyer-Villiger (BV) reaction in the synthesis of natural products and steroid-peptide conjugates, we report here some of our findings of BV oxidation of carbonyl compounds with special reference to steroidal ketones under MW irradiation justifying its accelerating effect.
The role of ceric ammonium nitrate (CAN) as an effective catalyst in the peracid induced Baeyer-Villiger oxidation of carbonyl compounds with special reference to steroids has been demonstrated.
THE BIOTRANSFORMATION OF SOME STEROIDS BY CEPHALOSPORIUM APHIDICOLA
Hydroxylation of 5α-androstane-3-one and 3,6-dione by C. aphidicla takes place at C-17β and, in the case of the latter, at C-5α.The fungus reduces 5α-androstan-17-one and the 3,17-dione to the 17β-alcohols. Key Word Index - Cephalosporium aphidicola; fungus; microbiological hydroxylation; steroids.
Hanson, James R.,Nasir, Habib
p. 831 - 834
(2007/10/02)
Desulphurization of the thioketal of testosterone acetate with deactivated Raney nickel.
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Permutti,Danieli,Mazur
p. 5425 - 5431
(2007/10/13)
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