- Quinoline derivatives having anti-tumor activity
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The invention relates to a quinoline of the formula: STR1 wherein each of R1 and R2, which may be the same or different, is hydrogen, halogeno, hydroxy, cyano, carbamoyl, nitro or amino, alkyl, alkoxy, alkylthio, alkylamino, dialkyla
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- Quinoline antifolate thymidylate synthase inhibitors: Variation of the C2- and C4-substituents
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Modifications to the bicyclic ring system of the potent thymidylate synthase (TS) inhibitor N-[4-[N-[(2-amino-3,4-dihydro-4-oxo-6- quinazolinyl)methyl]-N-prop-2-ynylamino]benzoyl]-L-glutamic acid (1, CB3717) have led to the synthesis of a series of quinol
- Warner,Barker,Jackman,Burrows,Roberts,Bishop,O'Connor,Hughes
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p. 2761 - 2768
(2007/10/02)
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