1239875-86-5

Basic information

• Product Name: SGI 7079
• Synonyms: 3-[2-[[3-Fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzeneacetonitrile;SGI 7079;SGI-7079 /SGI7079
• CAS NO: 1239875-86-5
• Molecular Formula: C26H26FN7
• Molecular Weight: 455.5299432
• Mol File: 1239875-86-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: SGI 7079(CAS DataBase Reference)
• NIST Chemistry Reference: SGI 7079(1239875-86-5)
• EPA Substance Registry System: SGI 7079(1239875-86-5)

Safety Data

• Hazardous Substances Data: 1239875-86-5(Hazardous Substances Data)

Usage

Uses

Used in Anticancer Applications:
SGI-7079 is used as an anticancer agent for its ability to inhibit the receptor tyrosine kinase Axl, which is often overexpressed in various cancers. This inhibition leads to a decrease in the proliferation of inflammatory breast cancer cells (IC50s = 0.43 and 0.15 μM for SUM149 and KPL-4 cells, respectively), a reduction in invasion, and the halting of the cell cycle in the G1 phase.
Used in Combination Therapy:
SGI-7079 is used as a synergistic agent in combination therapy with erlotinib, an EGFR inhibitor. The combination of SGI-7079 and erlotinib increases the potency of erlotinib on EGFR inhibition, providing a more effective treatment option for cancer patients.
Used in Non-Small Cell Lung Cancer Treatment:
In a mouse xenograft model of non-small cell lung cancer, SGI-7079 is used as a tumor growth inhibitor. It dose-dependently inhibits tumor growth, with the effect being greater when used in combination with erlotinib.
Used in Pharmaceutical Research and Development:
SGI-7079 is used as a research compound in the development of new cancer treatments targeting the Axl receptor tyrosine kinase. Its ability to inhibit Axl makes it a valuable tool in understanding the role of Axl in cancer progression and the potential for targeted therapies.
Used in Drug Delivery Systems:
While not explicitly mentioned in the provided materials, SGI-7079 could potentially be used in drug delivery systems to improve its bioavailability, delivery, and therapeutic outcomes, similar to the application of gallotannin in drug delivery systems.

Relevant articles and documents

Pyrrolopyrimidinyl axl kinase inhibitors

Compounds represented by Formula (I): are useful in treating diseases, such as cancer, that are mediated and/or associated (at least in part) with Axl kinase. The compounds can be formulated as pharmaceutically acceptable compositions for administration t