- Development of a robust immobilized organocatalyst for the redox-neutral mitsunobu reaction
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A polystyrene-supported version of the Denton catalyst for redox-neutral Mitsunobu reactions, (2-hydroxybenzyl)diphenylphosphine oxide, has been developed and used in catalytic inversion of enantiopure secondary alcohols (21 examples, up to 97% yield and 98% ee) with 2-nitrobenzoic and 2,4-dinitrobenzoic acids. The use in the reaction of alternative pronucleophiles has also been explored (8 successful and 3 unsuccessful examples). The functional resin shows high recyclability (10 cycles, 30 days operation) and can be re-activated by simple treatment with butylamine with further extension of its useful life.
- Lai, Junshan,Llanes, Patricia,Mastandrea, Marco M.,Pericàs, Miquel A.,Perulli, Stefania,Zhou, Leijie
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supporting information
p. 8859 - 8864
(2021/11/23)
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- 3-(BIARYLOXY) PROPIONIC ACID DERIVATIVE
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A compound of the general formula (I): [wherein, R1 represents a halogen atom, or the like, R2 represents a hydrogen atom, or the like, R3 and R4, each independently, represent a hydrogen atom, a C1-4
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Page/Page column 51
(2012/07/14)
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