1241009-48-2 Usage
Uses
Used in Pharmaceutical Industry:
[1-(3-Chloro-benzyl)-piperidin-4-yl]-methanol is used as a chemical intermediate for the development of new pharmaceuticals. Its structural properties allow it to potentially interact with various biological targets, making it a promising candidate for the creation of novel drugs.
Used in Research and Development:
In the field of research and development, [1-(3-Chloro-benzyl)-piperidin-4-yl]-methanol serves as a valuable compound for studying its interactions with different biological systems. This can lead to a better understanding of its potential applications and the discovery of new therapeutic approaches.
Used in Chemical Synthesis:
[1-(3-Chloro-benzyl)-piperidin-4-yl]-methanol can be utilized as a key component in the synthesis of more complex molecules, which may have specific applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 1241009-48-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,1,0,0 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1241009-48:
(9*1)+(8*2)+(7*4)+(6*1)+(5*0)+(4*0)+(3*9)+(2*4)+(1*8)=102
102 % 10 = 2
So 1241009-48-2 is a valid CAS Registry Number.
1241009-48-2Relevant articles and documents
Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine N-benzylpiperidine fragments
Zhou, Yeheng,Sun, Wei,Peng, Jiale,Yan, Hui,Zhang, Li,Liu, Xingyong,Zuo, Zhili
supporting information, (2019/10/08)
Cholinergic depletion is the direct cause of disability and dementia among AD patients. AChE is a classical and key target of cholinergic disorders. Some new inhibitors of AChE combining pyridine, acylhydrazone and N-benzylpiperidine fragments were developed in this work. The hit structure was optimized to yield the compound 21 with an IC50 value of 6.62 nM against AChE, while almost no inhibitory effect against BChE. ADMET predictions and PAMPA permeability evaluation showed good drug-like property. The higher activity with an intermediate alkyl chain substitution indicates a new binding mode of inhibitor with AChE. This finding provides new insights into the binding mechanism and is helpful for discovery of novel high-activity AChE inhibitors.
