- Synthesis of labeled ambroxol and its major metabolites
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Ambroxol is a mucolytic agent used in the treatment of respiratory diseases. Herein, we report the synthesis of carbon-14-labeled ambroxol with the radioactive atom(s) either on the benzylic carbon or uniformly in the cyclohexyl ring with specific activities of 59 and 81 mCi/mmol, respectively. We also describe the preparation of deuterium-labeled ambroxol, its deuterium-labeled tetrahydroquinazoline metabolite (DHTQ), carbon-13-labeled 3,5-dibromoanthranilic acid metabolite, as well as an unlabeled O-glucuronide conjugate. Copyright
- Latli, Bachir,Hrapchak, Matt,Switek, Heinz-Karl,Retz, Daniel M.,Krishnamurthy, Dhileepkumar,Senanayake, Chris H.
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experimental part
p. 15 - 23
(2010/04/26)
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