Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons
The synthesis of several novel 5α- and 5β-20-oxo-pregnane derivatives substituted in the position 3 and 7 of the steroid skeleton is described. Activity of synthesized compounds was studied in voltage-clamped cultured rat hippocampal neurons. Substituted
Stastna, Eva,Chodounska, Hana,Pouzar, Vladimir,Kapras, Vojtech,Borovska, Jirina,Cais, Ondrej,Vyklicky Jr., Ladislav