- Solid Phase Synthesis of Sulfonimidamide Pseudopeptides and Library Generation
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Many synthetic routes have been explored to make small molecule sulfonimidamides (SIAs), however, its introduction into larger molecules such as oligopeptides has not been studied before. We herein demonstrate three alternative and complementary methods f
- Chinthakindi, Praveen K.,Benediktsdottir, Andrea,Arvidsson, Per I.,Chen, Yantao,Sandstr?m, Anja
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- Overcoming the Deallylation Problem: Palladium(II)-Catalyzed Chemo-, Regio-, and Stereoselective Allylic Oxidation of Aryl Allyl Ether, Amine, and Amino Acids
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We report herein a Pd(II)/bis-sulfoxide-catalyzed intramolecular allylic C-H acetoxylation of aryl allyl ether, amine, and amino acids with the retention of a labile allyl moiety. Mechanistically, the reaction proceeds through a distinct double-bond isomerization from the allylic to the vinylic position followed by intramolecular carboxypalladation and the β-hydride elimination pathway. For the first time, C-H oxidation of N-allyl-protected amino acids to furnish five-membered heterocycles through 1,3-syn-addition is established with excellent diastereoselectivity.
- Begam, Hasina Mamataj,Jana, Ranjan,Manna, Kartic,Samanta, Krishanu
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p. 7443 - 7449
(2020/10/09)
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- Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents
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Polymer-supported reagents and sequestering agents may be used to generate an array of variously substituted hydroxamic acid derivatives as potential inhibitors of matrix metalloproteinases without any chromatographic purification step.
- Caldarelli, Marina,Habermann, Joerg,Steven V, Ley
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p. 2049 - 2052
(2007/10/03)
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