- Synthesis, Resolution, and SAR of (+/-)-2-Amino-N-methyl-α-(3-methyl-2-thienyl)benzeneethanamine and Related Analogs as Noncompetitive NMDA Antagonists with Neuroprotective Properties
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The preparation and structure-activity relationships of a series of 2-amino-α-thienylbenzeneethanamines are described.From this work, (+/-)-2-amino-N-methyl-α-(3-methyl-2-thienyl)-benzeneethanamine (3a) and the homologous N-ethyl analog 3b emerged as nove
- Martin, Lawrence L.,Lee, George E.,Lee, Thomas B. K.,Rush, Douglas K.,Wilmot, Carole A.,et al.
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p. 3008 - 3015
(2007/10/02)
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- 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines
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Novel 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines, intermediates, processes for the preparation thereof, and methods for treating depression, inhibiting convulsions and treating anxiety utilizing compounds and compositions thereof are disclosed.
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