Highly selective κ-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivatives
This paper describes the chemical synthesis, μ/κ opioid receptor selectivity and analgesic activity of 14 novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivatives. The prototype κ-selective agonist, PD117302 (trans-N-methyl-N-
Halfpenny,Horwell,Hughes,Hunter,Rees
p. 286 - 291
(2007/10/02)
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