124467-23-8

Basic information

• Product Name: 2-Chloro-8-fluoroquinoline
• Synonyms: 2-Chloro-8-fluoroquinoline
• CAS NO: 124467-23-8
• Molecular Formula: C₉H₅ClFN
• Molecular Weight: 181.5941032
• Mol File: 124467-23-8.mol

Chemical Properties

• Melting Point: 82-84℃
• Boiling Point: 271.3±20.0 °C(Predicted)
• Appearance: /
• Density: 1.366±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: -2.73±0.50(Predicted)
• CAS DataBase Reference: 2-Chloro-8-fluoroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-8-fluoroquinoline(124467-23-8)
• EPA Substance Registry System: 2-Chloro-8-fluoroquinoline(124467-23-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 124467-23-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Medicinal Applications:
2-Chloro-8-fluoroquinoline is used as an active pharmaceutical ingredient for its antimicrobial and antiparasitic properties, contributing to the development of treatments for various infections and parasitic diseases.
Used in Agrochemical Production:
2-Chloro-8-fluoroquinoline is utilized as a key intermediate in the synthesis of agrochemicals, playing a role in the development of pesticides and other agricultural products to protect crops and enhance yields.
Used in Specialty Chemicals:
2-Chloro-8-fluoroquinoline is employed as a building block in the production of specialty chemicals, where its unique structure and reactivity are leveraged to create novel compounds for specific industrial applications.
Used in Organic Synthesis:
As a versatile starting material, 2-Chloro-8-fluoroquinoline is used in organic synthesis for the preparation of a wide range of organic compounds, including potential drug candidates and other chemical entities with specific applications.

Upstream product

• 612-62-4 2-Chloroquinoline 
• 71738-83-5 8-fluoroquinolin-2(1H)-one 
• 348-54-9 2-Fluoroaniline 
• 1065481-24-4 (2E)-N-(2-fluorophenyl)-3-phenylprop-2-enamide 
• 71738-83-5 2-hydroxy-8-fluoroquinoline 

Downstream Products

• 71738-83-5 2-hydroxy-8-fluoroquinoline 
• 1065481-27-7 (R)-1-(2-chloro-8-fluoroquinolin-3-yl)ethanol 
• 1464832-35-6 2-((1S)-1-(8-fluoro-2-(2-(methylthio)phenyl)quinolin-3-yl)ethyl)isoindoline-1,3-dione 
• 1464832-37-8 2-((1S)-1-(8-fluoro-2-(2-(methylsulfonyl)phenyl)-3-quinolinyl)ethyl)-1H-isoindole-1,3(2H)-dione 
• 1464832-39-0 (1S)-1-(8-fluoro-2-(2-(methylsulfonyl)phenyl)-3-quinolinyl)ethanamine 
• 1464832-30-1 4-amino-6-(((1S)-1-(8-fluoro-2-(2-(methyl-sulfonyl)phenyl)-3-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile 
• 1065478-86-5 N-((S)-1-(8-fluoro-2-(3-fluorophenyl)quinolin-3-yl)ethyl)-9H-purin-6-amine 
• 1065481-30-2 (1S)-1-(8-fluoro-2-(3-fluorophenyl)quinolin-3-yl)ethanamine 
• 1065481-29-9 3-((S)-1-azidoethyl)-8-fluoro-2-(3-fluorophenyl)quinoline 
• 1065481-28-8 (S)-3-(1-azidoethyl)-2-chloro-8-fluoro-quinoline 

Relevant articles and documents

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Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

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