Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof
A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV), which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI), followed by hydrolysis to obtain Cinacalcet free base.
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(2012/01/13)
A NEW METHOD FOR THE PREPARATION OF CINACALCET AND NEW INTERMEDIATES THEREOF
A new method for the preparation of Cinacalcet by treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative which is further treated with 1 -(3-hdopropyl)-3-(triflupromethyl) benzene of formula (V) to obtain an iminium salt and followed by hydrolysis to obtain Cinacalcet free base. A new compound, (1R)- I-(2-naphthyl)-N-(aryhnethylene)ethanamine, of formula (IV) and an iminium salt compound of formula (VI) are disclosed. which are intermediates for the preparation of Cinacalcet.
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(2010/10/03)
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