Synthesis and structure-activity relationship of N-(3-azabicyclo[3.1.0]hex- 6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists
A novel class of small molecule NPY Y5 antagonists based around an azabicyclo[3.1.0]hexane scaffold was identified through modification of a screening hit. Structure-activity relationships and efforts undertaken to achieve a favourable pharmacokinetic profile in rat are described.
Biagetti, Matteo,Leslie, Colin Philip,Mazzali, Angelica,Seri, Catia,Pizzi, Domenica Antonia,Bentley, Jonathan,Genski, Thorsten,Fabio, Romano Di,Zonzini, Laura,Caberlotto, Laura
scheme or table
p. 4741 - 4744
(2010/10/04)
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