Synthesis and biological evaluation of a series of aromatic bisphosphonates
Geminal bisphosphonates display varied biological activity depending on the nature of the substituents on the central carbon atom. For example, the nitrogenous bisphosphonates zoledronate and risedronate inhibit the enzyme farnesyl diphosphate synthase wh
Barney, Rocky J.,Wasko, Brian M.,Dudakovic, Amel,Hohl, Raymond J.,Wiemer, David F.
Prenylated Bisphosphonates as Anti-tuberculosis Agents
The invention provides methods to treat a mycobacterium infection and methods to inhibit mycobacterial polyprenyl pyrophosphate synthesis with a compound of formula I. The invention also provides novel compounds of formula I as well as salts and prodrugs
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(2010/10/03)
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