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CAS

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1246638-08-3

N-DeMethyl Ivabradine Hydrochloride, also known as N-desmethyl Ivabradine, is an active metabolite of the pharmaceutical drug Ivabradine. It is produced through the metabolism of Ivabradine by the cytochrome P450 (CYP) isoform CYP3A4. This beige solid is a key component in understanding the drug's efficacy and pharmacokinetics.

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  • 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one

    Cas No: 1246638-08-3

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  • 1246638-08-3 Structure

  • Basic information

    1. Product Name: N-DeMethyl Ivabradine Hydrochloride
    2. Synonyms: N-DeMethyl Ivabradine Hydrochloride;3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]aMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-3-benzazepin-2-one Hydrochloride;S 18982;N-DesMethyl Ivabradine Hydrochloride;Ivabradine metabolite N-Demethyl Ivabradine (hydrochloride);N-Desmethyl Ivabradine HCl;Ivabradine Impurity b;N-Demethyl Ivabradine-d6 HCl
    3. CAS NO:1246638-08-3
    4. Molecular Formula: C26H35ClN2O5
    5. Molecular Weight: 491.0195
    6. EINECS: N/A
    7. Product Categories: Amines;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
    8. Mol File: 1246638-08-3.mol

  • Chemical Properties

    1. Melting Point: 193-196°C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Refrigerator
    8. Solubility: N/A
    9. CAS DataBase Reference: N-DeMethyl Ivabradine Hydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-DeMethyl Ivabradine Hydrochloride(1246638-08-3)
    11. EPA Substance Registry System: N-DeMethyl Ivabradine Hydrochloride(1246638-08-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1246638-08-3(Hazardous Substances Data)

1246638-08-3 Usage

Uses

Used in Pharmaceutical Industry:
N-DeMethyl Ivabradine Hydrochloride is used as a research compound for studying the metabolism and pharmacological effects of Ivabradine. It aids in understanding the drug's mechanism of action, bioavailability, and potential side effects, which is crucial for optimizing therapeutic applications and dosages.
Used in Drug Development:
As an active metabolite, N-DeMethyl Ivabradine Hydrochloride is utilized in drug development processes to evaluate the safety and efficacy of Ivabradine. It helps in assessing the drug's potential for treating specific conditions and contributes to the overall development of new medications.
Used in Quality Control:
N-DeMethyl Ivabradine Hydrochloride is used as a reference standard in quality control testing for Ivabradine-containing pharmaceutical products. It ensures that the drug meets the required purity and potency standards, maintaining the safety and efficacy of the medication for patients.

Check Digit Verification of cas no

The CAS Registry Mumber 1246638-08-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,6,6,3 and 8 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1246638-08:
(9*1)+(8*2)+(7*4)+(6*6)+(5*6)+(4*3)+(3*8)+(2*0)+(1*8)=163
163 % 10 = 3
So 1246638-08-3 is a valid CAS Registry Number.

1246638-08-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one,hydrochloride

1.2 Other means of identification

Product number -
Other names N-Demethylivabradine Hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1246638-08-3 SDS

1246638-08-3Upstream product

1246638-08-3Downstream Products

1246638-08-3Relevant articles and documents

Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

-

Page/Page column 4, (2010/10/19)

Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.

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