- Synthesis and evaluation of novel phosphate ester analogs as neutral sphingomyelinase inhibitors
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A novel sphingomyelin inhibitor RY221B-a, which contains a bipyridyl moiety as a metal coordination site was designed based upon the mechanism of phosphate ester hydrolysis. RY221B-a was synthesized from N-Boc-sphingosine in three steps via selective etherification using stannyl acetal. Synthesized RY221B-a exhibited relatively-strong inhibitory activity against Bc-SMase (IC 50 = 1.2 μM).
- Imagawa, Hiroshi,Oda, Masataka,Takemoto, Takayuki,Yamauchi, Rieko,Yoshikawa, Tomomi,Yamamoto, Hirofumi,Nishizawa, Mugio,Takahashi, Hironobu,Hashimoto, Manabu,Yabiku, Kenta,Nagahama, Masahiro,Sakurai, Jun
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supporting information; experimental part
p. 3868 - 3871
(2010/09/03)
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- SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR
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An object of the invention is to provide a novel sphingosine compound with an inhibitory activity against sphingomyelinase, and a method for producing the sphingosine compound. The novel sphingosine compound or a salt thereof according to the invention is represented by Formula (1): wherein one of R1 and R2 is hydrogen, and the other is a group represented by Formula (G): wherein n is 0 or 1; and R3 is hydrogen, C1-23 alkyl, C3-8 cycloalkyl, C2-6 alkenyl, C1-6 alkoxy, C3-8 cycloalkyloxy, phenyl, or furil.
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Page/Page column 14
(2009/12/27)
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- Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells
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Allergic diseases are hypersensitivity disorders associated with the production of specific immunoglobulin E (IgE) to environmental allergens. Interleukin (IL)-4, produced primarily by CD4+ T cells, is an important stimulus for the switch of th
- Park, Jin,Li, Qian,Chang, Young-Tae,Kim, Tae Sung
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p. 2589 - 2595
(2007/10/03)
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- The synthesis and biological characterization of a ceramide library
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A facile synthesis of a combinatorial ceramide library and their activities in the NF-κB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-κB activating molecule was discovered among ceramide containing β-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated. Copyright
- Chang, Young-Tae,Choi, Jaehwa,Ding, Sheng,Prieschl, Eva E.,Baumruker, Thomas,Lee, Jae-Mok,Chung, Sung-Kee,Schultz, Peter G.
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p. 1856 - 1857
(2007/10/03)
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