The discovery and optimization of a series of 2-aminobenzoxazole derivatives as ChemR23 inhibitors
A structural class of 2-aminobenzoxazole derivatives possessing biphenyltetrazole was discovered to be potent human ChemR23 inhibitors. We initially tried to improve the potency of compound 1, which was found through in-house screening using the human pla
Biphenyl derivatives represented by the following formula (1): wherein R1 represents a C5-7 alkyl group, R2 represents a substituted or unsubstituted aromatic hydrocarbon, or cycloalkyl group, R3 represents a te
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Page/Page column 14-15
(2008/06/13)
Biphenylmethyl-substituted pyridones
Biphenylmethyl-substituted pyridones are prepared by reaction of pyridones with appropriate biphenylmethyl compounds. The biphenylmethyl-substituted pyridones can be employed as active compounds in medicaments, in particular for the treatment of arter
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(2008/06/13)
SUBSTITUTED TRIAZOLINONES, TRIAZOLINETHIONES, AND TRIAZOLINIMINES AS ANGIOTENSIN II ANTAGONISTS
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(2008/06/13)
SUBSTITUTED PYRAZOLE ANGIOTENSIN II ANTAGONISTS
Substituted pyrazoles such as STR1 and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
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(2008/06/13)
TREATMENT OF HYPERTENSION WITH 1,2,4-ANGIOTENSIN II ANTAGONISTS
Substituted pyrroles, pyrazoles and traizoles such as STR1 and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
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(2008/06/13)
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