Synthesis and nematocidal activities of new analogs of pyrantel
A set of new analogs of pyrantel was synthesized in good yields by lithiation of 1,2-dimethyltetrahydropyrimidine with n-butyllithium in tetrahydrofuran and condensation with aromatic esters.Spetrometric studies showed the large influence of intra molecular bonding in the tautomeric equilibria between the possible structures.Anthelmintic screening showed in vitro efficiency against Molinema dessetae, but a weak activity against Rhabditis pseudoelongata and Nippostrongylus brasiliensis. tetrahydropyrimidine / pyrantel / tautomeric equilibrium/ nematocide
Kraouti, N.,Caujolle, R.,Labidalle, S.,Payard, M.,Loiseau, P. M.,et al.
p. 509 - 514
(2007/10/02)
SYNTHESIS OF BENZOYL SUBSTITUTED HETEROCYCLIC KETENE AMINALS BY CONDENSATION OF BENZOYL KETENE MERCAPTALS WITH DIAMINES
2-(Benzoylmethylene)imidazolidines 2 and 5, -hexahydropyrimidines 3 and 6, or -hexahydro-1H-1,3-diazepines 4 were synthesized by the reaction of benzoyl substituted ketene mercaptals 1 with diamines.
Huang, Zhi-tang,Liu, Zhi-rong
p. 943 - 958
(2007/10/02)
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