- Synthesis of fluorinated triazole and isoxazole derivatives by electrochemical fluorination
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Partially fluorinated triazole derivatives were synthesized through anodic fluorination of alkynes having arylthio group and following Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with benzyl azide. The other route toward the fluorinated triazoles,
- Kuribayashi, Shunsuke,Shida, Naoki,Inagi, Shinsuke,Fuchigami, Toshio
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- Triazolyl RuII, RhIII OsII, and IrIII Complexes as Potential Anticancer Agents: Synthesis, Structure Elucidation, Cytotoxicity, and DNA Model Interaction Studies
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Novel conjugated ruthenium(II), rhodium(III), and iridium(III) organometallic complexes of triazoles 1 and 2 synthesized and evaluated for anticancer activity against cervical (HeLa), kidney (HEK293), nonsmall lung cancer (A549), and leukemia (MT4) cancer cell lines are reported herein. The complexes are κ2-N,C coordinated and have the formula [ML(Ar)Cl] (where L is 1-benzyl-4-phenyl-1H-1,2,3-triazole for 1 and 1-benzyl-4-hydroxymethyl-1H-1,2,3-triazole for 2, Ar is p-cymene for RuII and OsII and Cp? for RhIII and IrIII, and M is metal). NMR studies, including HMBC and NOESY, were employed to unambiguously elucidate their structures and provide their conformational information in solution. Single-crystal X-ray diffraction data have been used to establish the solid-state structures of selected complexes, which further confirm the structural elucidation by NMR. Dynamic NMR studies, such as differential transferred NOE, have been employed to distinguish between isomers 1a_I and 1a_II of ruthenium(II) complexes of triazole 1. The rhodium(III) (1b) and iridium(III) (1c) complexes exhibited good cytotoxic activities (CC50 = 4-6 μM) comparable to that of the drug auranofin against lung cancer A549 cell lines (CC50 = 4.69 μM). While triazole 1 based ruthenium(II) (1a) and osmium(II) (1d) complexes displayed modest anticancer activities against HeLa and HEK293 cell lines, the analogous rhodium(III) and iridium(III) complexes exhibited good potential (CC50 = 9-54 μM versus auranofin (3-9 μM)) against these cancer cell lines. Insightful NMR studies on the interaction between the DNA model guanosine 5′-GMP and the complexes 1b,c reveal a possible mode of action of the aquated complexes involving carbenylation with DNA bases or purines through the triazolyl proton H-5. From the findings, these complexes could possibly confer their cytotoxic activities through intercalation with the DNA of pathological cells. Therefore, carbenylation of the triazolylrhodium(III) and iridium(III) complexes by DNA guanosine 5′-GMP is proposed as a novel mode of DNA intercalation of these complexes in cancer cells.
- Rono, Charles K.,Chu, William K.,Darkwa, James,Meyer, Debra,Makhubela, Banothile C. E.
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- Selective aerobic oxidation of benzylic and allylic alcohols catalyzed by Cu(OAc)2/TEMPO/Et2NH
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Selective oxidation of benzylic and allylic alcohols to their corresponding aldehyde/ketone derivative without affecting saturated alcohols is still a challenging endeavor in organic synthesis. Various metal complexes, especially the copper complexes in the presence of TEMPO are being used very often for such transformations under aerobic conditions, but they are not selective to allylic and benzylic alcohols. The use of copper salt for oxidation of alcohols in the absence of a ligand are very scarcely studied except for the one catalyzed by CuCl/TEMPO where chloride inhibition and lack of selective oxidation have been noted upon use of CuCl2. Herein we report a Cu(OAc)2 catalyzed and TEMPO mediated selective aerobic oxidation of benzylic and allylic alcohols to aldehyde/ketone in the presence of Et2NH. The method avoids pre-synthesis of the catalyst as in the case of Cu(II)/(I) complexes/TEMPO catalyzed oxidation reactions, requires low catalyst loading, employs cheaper copper salt, and gives excellent selectivity for oxidation of benzylic and allylic alcohols.
- Bez, Ghanashyam,Gogoi, Achinta,Pasupuleti, Bala Gangadhar
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p. 589 - 597
(2021/09/28)
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- Tuning the optical properties of BODIPY dyes by N-rich heterocycle conjugation using a combined synthesis and computational approach
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The increased number of N-atoms induced a blueshift in absorption and a gain in fluorescence quantum yield, from 750 nm and ~0% for pyrrole to 635 nm and ~40% for triazole, respectively. DFT calculations indicated a decrease in HOMO energy levels with the
- Banala, Srinivas,Kiessling, Fabian,Merkes, Jean Michel,Ostlender, Tobias,Sun, Haitao,Wang, Fufang
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supporting information
p. 19641 - 19645
(2021/11/12)
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- Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles
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A series of 6-amidinobenzothiazoles, linked via phenoxymethylene or directly to the 1,2,3-triazole ring with a p-substituted phenyl or benzyl moiety, were synthesised and evaluated in?vitro against four human tumour cell lines and the protozoan parasite T
- Racané, Livio,Rep, Valentina,Kraljevi? Paveli?, Sandra,Grb?i?, Petra,Zonji?, Iva,Radi? Stojkovi?, Marijana,Taylor, Martin C.,Kelly, John M.,Rai?-Mali?, Silvana
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p. 1952 - 1967
(2021/09/03)
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- Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds
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Functionalised triazole aldehydes are used in the highly selective self-assembly of water-compatible, optically pure, low symmetry Fe(ii)- and Zn(ii)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cel
- Brabec, Viktor,Clarkson, Guy J.,Coverdale, James P. C.,Kostrhunova, Hana,Phillips, Roger M.,Postings, Miles,Rogers, Nicola J.,Scott, Peter,Shepherd, Samantha L.,Song, Hualong
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supporting information
p. 6392 - 6395
(2020/06/21)
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- Triazolecarbaldehyde Reagents for One-Step N-Terminal Protein Modification
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Site-specific modification of peptides and proteins is a key aspect of protein engineering. We developed a method for modification of the N terminus of proteins using 1H-1,2,3-triazole-4-carbaldehyde (TA4C) derivatives, which can be prepared in one step. The N-terminal specific labeling of bioactive peptides and proteins with the TA4C derivatives proceeds under mild reaction conditions in excellent conversion (angiotensin I: 92 %, ribonuclease A: 90 %). This method enables site-specific conjugation of various functional molecules such as fluorophores, biotin, and polyethylene glycol attached to the triazole ring to the N terminus. Furthermore, a functional molecule modified with a primary amine moiety can be directly converted into a TA4C derivative through a Dimroth rearrangement reaction with 1-(4-nitrophenyl)-1H-1,2,3-triazole-4-carbaldehyde. This method can be used to obtain N-terminal-modified proteins via only two steps: 1) convenient preparation of a TA4C derivative with a functional group and 2) modification of the N terminus of the protein with the TA4C derivative.
- Onoda, Akira,Inoue, Nozomu,Sumiyoshi, Eigo,Hayashi, Takashi
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p. 1274 - 1278
(2020/01/25)
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- A molybdenum based metallomicellar catalyst for controlled and chemoselective oxidation of activated alcohols in aqueous medium
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A surfactant based oxodiperoxo molybdenum complex, which could activate molecular oxygen, has been employed as a catalyst for controlled oxidation of benzylic alcohols to corresponding carbonyls. The oxidation reactions were carried out under aqueous environment, however, in the absence of any extraneous base or co-catalyst. Sensitive/oxidizable functional groups like cyano, sulfide, hydroxyl, aryl-hydroxyl, alkene (internal/terminal), alkyne (internal/terminal), and acetal were tolerated during the transformations. Such selectivity is attributed to the mild nature of the catalyst. The methodology could also be scaled-up for multi-gram synthesis and the protocol is likely to find practical use since it requires an inexpensive recyclable-catalyst and easily available oxidant (under green conditions). A plausible mechanism is proposed with the help of preliminary computational study.
- Thiruvengetam, Prabaharan,Chakravarthy, Rajan Deepan,Chand, Dillip Kumar
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p. 123 - 133
(2019/07/19)
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- Reactions of α-haloacroleins with azides: Highly regioselective synthesis of formyl triazoles
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A general metal-free route to 1,4-disubstituted and 1,4,5-trisubstituted 1,2,3-triazoles was developed. α-Haloacroleins reacted with organic azides in a DMSO/H2O mixture solvent at room temperature to produce 1,4-disubstituted triazoles (up to 99%) with exclusive regioselectivities. This protocol is convenient and scalable with a broad substrate scope including aliphatic and aromatic azides. The resulting triazoles exhibited an aldehyde group at the C4 position and demonstrated synthetic utilizations. One 1,2,3-triazole compound containing diastereotopic protons was also identified.
- Zhang, Dongsheng,Fan, Yingzhu,Yan, Zhongliang,Nie, Yi,Xiong, Xingquan,Gao, Lizhu
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supporting information
p. 4211 - 4216
(2019/08/07)
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- Synthesis, spectroscopic characterization, and DFT studies of 1,2,3-triazole-based organosilicon compounds
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A series of triorgnosilicon compounds containing 1,2,3-triazole cores, tris(trimethylsilyl)ethyl) 1,2,3-triazoles (TTMSTs), tris(dimethyl(phenyl)silyl)ethyl) 1,2,3-triazoles (TDMPSTs), and bis(trimethylsilyl)vinyl) 1,2,3-triazoles (BTMSVTs) was synthesized and characterized by elemental analysis, FT-IR, 1H, 13C NMR spectroscopy, and density functional theory (DFT). The structure of the synthesized compounds was optimized using the B3LYP method of DFT at 6–311++G(d) basis set. Conjugate interactions or charge transfer in molecular systems was investigated using natural bond orbital (NBO) analysis. In addition, the FMOs (frontier molecular orbitals) and the associated band gaps were calculated and depicted. The mapped molecular electrostatic potential (MEP) surfaces of the title compounds were also calculated with the same level of theory.
- Mousazadeh, Hanieh,Safa, Kazem D.,Ghadari
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p. 200 - 208
(2018/06/19)
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- A multi-substituted three nitrogen zole derivatives preparation method (by machine translation)
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The present invention discloses a multi-substituted three nitrogen zole derivatives of the preparation method, comprises the following steps: the acrolein or acrolein derivatives, the corresponding azide compound or azido derivatives, strong acid and solv
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Paragraph 0064-0067
(2019/01/14)
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- Revisiting ring-degenerate rearrangements of 1-substituted-4-imino-1,2,3-triazoles
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The 1-substituted-4-imino-1,2,3-triazole motif is an established component of coordination compounds and bioactive molecules, but depending on the substituent identity, it can be inherently unstable due to Dimroth rearrangements. This study examined parameters governing the ring-degenerate rearrangement reactions of 1-substituted-4-imino-1,2,3-triazoles, expanding on trends first observed by L’abbé et al. The efficiency of condensation between 4-formyltriazole and amine reactants as well as the propensity of imine products towards rearrangement was each strongly influenced by the substituent identity. It was observed that unsymmetrical condensation reactions conducted at 70 °C produced up to four imine products via a dynamic equilibrium of condensation, rearrangement and hydrolysis steps. Kinetic studies utilizing 1-(4-nitrophenyl)-1H-1,2,3-triazole-4-carbaldehyde with varying amines showed rearrangement rates sensitive to both steric and electronic factors. Such measurements were facilitated by a high throughput colorimetric assay to directly monitor the generation of a 4-nitroaniline byproduct.
- Fletcher, James T.,Hanson, Matthew D.,Christensen, Joseph A.,Villa, Eric M.
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supporting information
p. 2098 - 2105
(2018/09/04)
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- Synthesis and cell imaging applications of fluorescent mono/di/tri-heterocyclyl-2,6-dicyanoanilines
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Synthesis of 3,4,5-triheterocyclyl-2,6-dicyanoanilines, starting from heterocyclic aldehydes and 1,2-diheterocycle-substituted ethanones, is described. 2,6-Dicyanoanilines with one or two heterocyclic substituents have also been synthesized. It was found
- Pisal, Mahesh M.,Annadate, Ritesh A.,Athalye, Meghana C.,Kumar, Deepak,Chavan, Subhash P.,Sarkar, Dhiman,Borate, Hanumant B.
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p. 979 - 988
(2017/02/10)
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- Tandem synthesis of 1-formyl-1,2,3-triazoles
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A tandem method for preparing 4-formyl-1,2,3-triazoles via a two-step one-pot acetal cleavage/CuAAC reaction was developed. Using this method, 4-formyl-1,2,3-triazole analogs with both electron-withdrawing and electron-donating substituents were prepared in good yield and purity. Expansion of this method to a three-step tandem reaction that incorporates an additional step of azide substitution was also successful, circumventing the need for organic azide isolation. This one-pot method, noteworthy in its simplicity and mild conditions, utilizes practical, readily available reactants and relies on protic solvent to promote acid-catalyzed acetal cleavage.
- Fletcher, James T.,Christensen, Joseph A.,Villa, Eric M.
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supporting information
p. 4450 - 4454
(2017/10/23)
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- A simple and efficient synthesis of organosilicon compounds containing 1,2,3-triazole moieties catalyzed by ZSM-5 zeolite-supported Cu–Co bimetallic oxides
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A new efficient procedure for preparation of 1,2,3-triazole derivatives by 1,3-dipolar cycloaddition of benzyl halides, sodium azide, and propargyl alcohol over Cu–Co/ZSM-5 bimetallic nanocatalyst in aqueous media under conventional heating and ultrasonic irradiation was developed. The maximum activity of the catalyst was reported under ultrasonic irradiation with a noticeable reduction in the reaction time. The generated products were utilized as substrates for the synthesis of a series of new 1,2,3-triazole derivatives containing organosilylvinyl substituent and bulky organosilicon groups using (RSiMe2)3CLi (R?=?Me, Ph). Graphical abstract: [Figure not available: see fulltext.]
- Safa, Kazem D.,Mousazadeh, Hanieh
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p. 1951 - 1961
(2016/10/21)
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- Synthesis of 2-triazolyl-imidazo[1,2-a]pyridine through a one-pot three-component reaction using a nano copper oxide assisted click-catalyst
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The syntheses of 2-triazolyl imidazo[1,2-a]pyridine (8a-o) were accomplished through three component A3 coupling followed by 5-exo dig cyclisation by employing 1-alkyl-1,2,3-triazole-4-carbaldehyde, amidine and terminal alkynes using 5 mol% nanocopper oxide together with 10 mol% sodium ascorbate as a click-catalyst in ethanol at 70 °C. The present protocol was further utilized for the synthesis of 2-(2-triazolyl-imidazo[1,2-a]pyridin-3-yl)ethanol (9a-e). In addition, the molecular structure of 8c possesses a C-H...π interaction (H17b...C10) along with a peculiar supramolecular layered structure architecture. This protocol features ready recyclability of the catalyst, good yields and wide substrate scope. Moreover, the syntheses of triazolyl precursors (1-alkyl-1,2,3-triazol-4-yl)methanol (4a-f) have also been achieved through a nano copper oxide mediated click-catalyst in water at 70 °C.
- Bagdi, Prasanta Ray,Basha, R. Sidick,Khan, Abu T.
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p. 61337 - 61344
(2015/08/03)
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- 'Click' ligand for 'click' chemistry: (1-(4-methoxybenzyl)-1-H-1,2,3-triazol-4-yl)methanol (MBHTM) accelerated copper-catalyzed [3+2] azide-alkyne cycloaddition (CuAAC) at low catalyst loading
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Readily accessible, cost effective, remarkably stable and easily tunable 1,2,3-triazole based ligand, (1-(4-methoxybenzyl)-1-H-1,2,3-triazol-4-yl)methanol (MBHTM) synthesized itself by 'click' chemistry shown to promote the dramatic rate enhancement of co
- Tale, Rajesh H.,Gopula, Venkatesh B.,Toradmal, Gopal K.
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supporting information
p. 5864 - 5869
(2015/11/02)
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- One-pot synthesis of TBTA-functionalized coordinating polymers
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A one-pot method for the functionalization of polyvinylbenzyl chloride with a tris-(benzyltriazolylmethyl)amine (TBTA) ligand via the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) is reported, where the ligand is constructed simultaneously
- Movahedi, Alireza,Moth-Poulsen, Kasper,Ekl?f, Johnas,Nydén, Magnus,Kann, Nina
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- 15N NMR spectroscopic and theoretical GIAO-DFT studies for the unambiguous characterization of disubstituted 1,2,3-triazoles
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The 1,2,3-triazole ring has recently attracted a renewed interest as a structural scaffold with many applications in different fields. However, very often, the unambiguous assignment of the correct structure is not an easy task, and the development of rob
- Corredor, Miriam,Bujons, Jordi,Messeguer, Angel,Alfonso, Ignacio
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p. 7318 - 7325
(2013/10/22)
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- Copper(I)-catalyzed aerobic oxidative azide-alkene cyclo-addition: An efficient synthesis of substituted 1,2,3-triazoles
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A novel, copper(I)-promoted azide-alkene aerobic oxidative cycloaddition protocol was devel-oped for the regioselective synthesis of 1,4-disubsti-tuted/ 1,4,5-trisubstituted 1,2,3-triazoles by using azides and electron-deficient olefins under an oxygen atmosphere.
- Janreddy, Donala,Kavala, Veerababurao,Kuo, Chun-Wei,Chen, Wen-Chang,Ramesh, Chintakunta,Kotipalli, Trimurtulu,Kuo, Ting-Shen,Chen, Mei-Ling,He, Chiu-Hui,Yao, Ching-Fa
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p. 2918 - 2927
(2014/03/21)
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- Copper-catalyzed huisgen 1,3-dipolar cycloaddition under oxidative conditions: Polymer-assisted assembly of 4-acyl-1-substituted-1,2,3-triazoles
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We herein document the first example of a reliable copper-catalyzed Huisgen 1,3-dipolar cycloaddition under oxidative conditions. The combined use of two polymer-supported reagents (polystyrene-1,5,7-triazabicyclo[4,4,0]dec-5-ene/Cu and polystyrene-2-iodoxybenzamide) overcomes the thermodynamic instability of copper(I) species toward oxidation, enabling the reliable Cu-catalyzed Huisgen 1,3-dipolar cycloadditions in the presence of an oxidant agent. This polymer-assisted pathway, not feasible under conventional homogeneous conditions, provides a direct assembly of 4-acyl-1-substituted-1,2,3-triazoles, contributing to expand the reliability and scope of Cu(I)-catalyzed alkyne-azide cycloaddition.
- Diz, Paula M.,Coelho, Alberto,El Maatougui, Abdelaziz,Azuaje, Jhonny,Caamano, Olga,Gil, Alvaro,Sotelo, Eddy
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p. 6540 - 6549
(2013/07/26)
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- Method for assigning structure of 1,2,3-triazoles
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1,4-Disubstituted-1H-1,2,3-triazoles 1 can easily be distinguished from the isomeric 1,5-disubstituted-1H-1,2,3-triazoles 2 by simple one-dimensional 13C NMR spectroscopy using gated decoupling. The C5 signal of 1 appears at δ ~120 p
- Creary, Xavier,Anderson, Andrew,Brophy, Carl,Crowell, Frances,Funk, Zachary
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p. 8756 - 8761
(2012/11/13)
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- Conventional and microwave assisted synthesis of 1,4-disubstituted 1,2,3-triazoles from Huisgen cycloaddition
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In this paper the synthesis of a library of new 1,4-disubstituted 1,2,3-triazoles 1, with a variety of additional functional groups on its structure, from an in situ generated benzyl azide 2 and different alkynes and dialkynes 3 is reported. Optimal exper
- Sarmiento-Sanchez, Juan I.,Ochoa-Teran, Adrian,Rivero, Ignacio A.
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experimental part
p. 177 - 188
(2011/08/07)
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- Tailored ligand acceleration of the cu-catalyzed azide-alkyne cycloaddition reaction: Practical and mechanistic implications
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Tris(heterocyclemethyl)amines containing mixtures of 1,2,3-triazolyl, 2-benzimidazoyl, and 2-pyridyl components were prepared for ligand acceleration of the copper-catalyzed azide-alkyne cycloaddition reaction. Two classes of ligands were identified: thos
- Presolski, Stanislav I.,Hong, Vu,Cho, So-Hye,Finn
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supporting information; experimental part
p. 14570 - 14576
(2010/12/24)
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- "click" synthesis of nonsymmetrical bis(1,2,3-triazoles)
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Chemical Fig. Repretation Unsymmetrically 1,1'-disubstituted 4,4'-bis-1 H-1,2,3-triazoles 4 have been prepared from 4-ethynyl-1,2,3-triazoles 5 and azides. Following a "double-click" strategy, two complementary approaches were implemented for the preparation of the key 4-ethynyltriazole Intermediates 5: (a) the stepwise Swern oxidatlon/Ohira-Bestman alkynylation of readily available 4-hydroxymethyl-1,2,3-triazoles 8 and (b) the stepwise cycloaddition of TMS-1,4-butadiyne 9. The method is highlighted by Its compatibility with orthogonally protected and functlonallzed saccharide-peptide hybrids and its ability to be extended to the trlsubstituted counterparts 12.
- Aizpurua, Jesus M.,Azcune, Itxaso,Fratila, Raluca M.,Balentova, Eva,Sagartzazu-Aizpurua, Malaien,Miranda, Jose I.
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supporting information; experimental part
p. 1584 - 1587
(2010/06/16)
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- Polymeric ligands as homogeneous, reusable catalyst systems for copper assisted click chemistry
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Tris-(benzyltriazolylmethyl)amine (TBTA) has been immobilized onto a styrenic monomer and subsequently copolymerized with styrene to afford catalytically active and reusable copolymers for the CuAAC reaction. The Royal Society of Chemistry 2010.
- Lammens, Mieke,Skey, Jared,Wallyn, Sofie,O'Reilly, Rachel,Du Prez, Filip
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scheme or table
p. 8719 - 8721
(2011/02/24)
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- Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood
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Tpl2 (cot/MAP3K8) is an upstream kinase of MEK in the ERK pathway. It plays an important role in Tumor Necrosis Factor-α (TNF-α) production and signaling. We have discovered that 8-halo-4-(3-chloro-4-fluoro-phenylamino)-6-[(1H-[1,2,3]triazol-4-ylmethyl)-a
- Wu, Junjun,Green, Neal,Hotchandani, Rajeev,Hu, Yonghan,Condon, Jeffrey,Huang, Adrian,Kaila, Neelu,Li, Huan-Qiu,Guler, Satenig,Li, Wei,Tam, Steve Y.,Wang, Qin,Pelker, Jeffrey,Marusic, Suzana,Hsu, Sang,Perry Hall,Telliez, Jean-Baptiste,Cui, Junqing,Lin, Lih-Ling
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scheme or table
p. 3485 - 3488
(2010/03/03)
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- Molecular Rearrangements of 4-Iminomethyl-1,2,3-Triazoles. Replacement of 1-Aryl Substituents in 1H-1,2,3-Triazole-4-carbaldehydes
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The two structural isomers, 4 and 5, of 1-substituted-4-iminomethyl-1,2,3-triazoles are interconvertible when heated in dimethyl sulfoxide at 80 deg C.The equilibrium position depends on the electronic properties of the R-substituent, favoring 5 for R = alkyl, benzyl and anisyl, and 4 for p-chlorophenyl and p-nitrophenyl.An interesting application is the synthesis of 1-alkyl-1,2,3-triazole-4-carbaldehydes from 1-phenyl-1,2,3-triazole-4-carbaldehyde by Scheme I.The hydrazones 4i, j and the oxime 4k do not rearrange due to an unfavorable Z-configuration around the C=N bond, whereas the acyloximino derivative 4m is converted into the nitrile 11.The structures of the products have been fully characterized by 13C nmr spectroscopy and the mechanistic details of the rearrangement are discussed.
- L'abbe, Gerrit,Bruynseels, Maria,Delbeke, Pieter,Toppet, Suzanne
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p. 2021 - 2027
(2007/10/02)
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- Replacement of Aryl by Alkyl in 1-Substituted 1H-1,2,3-Triazole-4-carbaldehydes
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1-Phenyl-1,2,3-triazole-4-carbaldehyde is readily transformed into 1-alkyl-1,2,3-triazole-4-carbaldehydes by thermal isomerization of the corresponding imines, followed by acid hydrolysis.
- L'abbe, Gerrit,Bruynseels, Maria
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p. 1492 - 1493
(2007/10/02)
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- SYNTHESIS OF C- AND N-SUBSTITUTED OXIRANYL-1,2,3-TRIAZOLES
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N-Substituted oxiranyl-1,2,3-triazoles are formed during the cycloaddition of glycidyl azide to various acetylene compounds or during the treatment of triazolylchloropropanols with alkali.The condensation of formyl-1,2,3-triazoles with chloroacetic ester
- Maksikova, A. V.,Serebryakova, E. S.,Shcherbakov, V. V.,Gareev, G. A.,Vereshchagin, L. I.
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p. 1371 - 1375
(2007/10/02)
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