1249639-43-7

Basic information

• Product Name: Tetrahydro-4-(methylamino)-2H-pyran-4-methanamine
• Synonyms: Tetrahydro-4-(methylamino)-2H-pyran-4-methanamine
• CAS NO: 1249639-43-7
• Molecular Formula: C7H16N2O
• Molecular Weight: 144
• Mol File: 1249639-43-7.mol

Chemical Properties

• Boiling Point: 227℃
• Flash Point: 91℃
• Appearance: /
• Density: 1.00
• PKA: 10.01±0.29(Predicted)
• CAS DataBase Reference: Tetrahydro-4-(methylamino)-2H-pyran-4-methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydro-4-(methylamino)-2H-pyran-4-methanamine(1249639-43-7)
• EPA Substance Registry System: Tetrahydro-4-(methylamino)-2H-pyran-4-methanamine(1249639-43-7)

Safety Data

• Hazardous Substances Data: 1249639-43-7(Hazardous Substances Data)

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 

Relevant articles and documents

Preparation method of 4-(aminomethyl)-N-alkyltetrahydro-2H-furan-4-amine

The invention relates to a preparation method of a medical intermediate, in particular to a preparation method of an amine substance of 4-(aminomethyl)-N-alkyltetrahydro-2H-furan-4-amine which is shown as a general formula I. The preparation method comprises the following steps: taking cyclic ketone as a raw material; making TMSCN (Trimethylsilyl Cyanide) and alkylamine react to obtain an amino cyanogen compound II; using sodium borohydride and a Ni-Al alloy together to reduce a cyano-group to obtain the 4-(aminomethyl)-N-alkyltetrahydro-2H-furan-4-amine (I). The 4-(aminomethyl)-N-alkyltetrahydro-2H-furan-4-amine (I) is taken as a medical intermediate for preventing pain or pruritus. In the synthetic method for the compound provided by the invention, use of highly-toxic compounds and flammable and explosive raw materials is avoided, so that the synthetic method can be more able to apply to an industrial mass production process.

NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF

Disclosed are a novel benzamide derivative and pharmaceutical use thereof, and more particularly, a novel benzamide derivative having a structure of Formula 1 or pharmaceutically acceptable salts thereof, and a composition for prevention or treatment of pain or itching including the above material. The novel benzamide derivative and pharmaceutically acceptable salt thereof according to the present invention exhibit excellent pain-suppressive effect and, in particular, pain-suppressive effect in not only a neuropathic animal model but also other models such as a formalin model, and therefore, may be used in suppression of different pains such as nociceptive pain, chronic pain, etc. Further, since it was demonstrated that the present invention displays anti-pruritic efficacy even in an itching model, to which a mechanism and treatment concept established with respect to pain is applied, the present invention may also be effectively used in radical treatment of atopic dermatitis by applying the inventive product to an anti-pruritic composition in order to suppress an initial itching stage and treat symptoms thereof, thus preventing skin damage or inflammation after the scratching stage.

NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF

Disclosed are a novel benzamide derivative and pharmaceutical use thereof, and more particularly, a novel benzamide derivative having a structure of Formula 1 or pharmaceutically acceptable salts thereof, and a composition for prevention or treatment of pain or itching including the above material. The novel benzamide derivative and pharmaceutically acceptable salt thereof according to the present invention exhibit excellent pain-suppressive effect and, in particular, pain-suppressive effect in not only a neuropathic animal model but also other models such as a formalin model, and therefore, may be used in suppression of different pains such as nociceptive pain, chronic pain, etc. Further, since it was demonstrated that the present invention displays anti-pruritic efficacy even in an itching model, to which a mechanism and treatment concept established with respect to pain is applied, the present invention may also be effectively used in radical treatment of atopic dermatitis by applying the inventive product to an anti-pruritic composition in order to suppress an initial itching stage and treat symptoms thereof, thus preventing skin damage or inflammation after the scratching stage.