Highly regioselective palladium-catalysed oxidative allylic C-H carbonylation of alkenes
Pd-catalysed direct oxidative carbonylation of allylic C-H bonds with carbon monoxide was first described. This new procedure shows that the inherent requirement for a leaving group in the Tsuji-Trost palladium-catalysed allylic carbonylation can be lifted, which provides a new route for accessing more synthetically useful β-enoic acid esters with high regioselectivity. The Royal Society of Chemistry 2011.
A highly selective and general palladium catalyst for the oxidative heck reaction of electronically nonbiased olefins
A general, highly selective oxidative Heck reaction is reported. The reaction is high-yielding under mild conditions without the need for base or high temperatures, and the selectivity is excellent, without the requirement for electronically biased olefins or other specific directing groups. A preliminary mechanistic investigation suggests that the unusually high selectivity may be due to the catalyst's sensitivity to C-H bond strength in the selectivity-determining β-hydride elimination step.
Werner, Erik W.,Sigman, Matthew S.
supporting information; experimental part
p. 13981 - 13983
(2010/12/24)
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