1251123-28-0Relevant articles and documents
Catalytic chemical amide synthesis at room temperature: One more step toward peptide synthesis
Mohy El Dine, Tharwat,Erb, William,Berhault, Yohann,Rouden, Jacques,Blanchet, Jér?me
, p. 4532 - 4544 (2015/05/13)
An efficient method has been developed for direct amide bond synthesis between carboxylic acids and amines via (2-(thiophen-2-ylmethyl)phenyl)boronic acid as a highly active bench-stable catalyst. This catalyst was found to be very effective at room temperature for a large range of substrates with slightly higher temperatures required for challenging ones. This methodology can be applied to aliphatic, α-hydroxyl, aromatic, and heteroaromatic acids as well as primary, secondary, heterocyclic, and even functionalized amines. Notably, N-Boc-protected amino acids were successfully coupled in good yields with very little racemization. An example of catalytic dipeptide synthesis is reported.
Synthesis and reactivities of dihydrosilanes tethered with two thioether moieties
Takeda, Nobuhiro,Nakamura, Tetsu,Imamura, Ayako,Unno, Masafumi
experimental part, p. 438 - 445 (2012/01/06)
Dihydrosilanes tethered with two thioether moieties, [2-(RSCH 2)C6H4]2SiH2(1a: R = t-Bu; 1b: R = i-Pr; 1c: R = Ph), were synthesized. Dihydrosilane 1b did not react with methanol, benzaldehyde, and ca
