Merging nucleophilic and hydrogen bonding catalysis: An anion binding approach to the kinetic resolution of propargylic amines
An efficient kinetic resolution of primary propargylic amines with s-factors of up to 56 is reported. The strategy is based on a dual catalytic approach, namely the use of a newly developed and easy-to-make thiourea-amide anion binding catalyst in combination with 4-(dimethylamino)pyridine (DMAP), both employed at a 5 mol % catalyst loading. Benzylic amines are also resolved with s-factors of up to 38.
Klauber, Eric G.,De, Chandra Kanta,Shah, Tejas K.,Seidel, Daniel
supporting information; experimental part
p. 13624 - 13626
(2010/11/17)
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