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N-(4-chlorophenyl)-1-(pyrimidin-2-yl)-1H-pyrrole-2-sulfonamide, also known as PTP1B inhibitor VIII, is a sulfonamide derivative with potential biological activities. It has been studied for its potential as a therapeutic agent for the treatment of various diseases, including cancer and diabetes. N-(4-chlorophenyl)-1-(pyrimidin-2-yl)-1H-pyrrole-2-sulfonamide inhibits the activity of protein tyrosine phosphatase 1B (PTP1B), an enzyme involved in the regulation of insulin and leptin signaling, making it a potential target for the development of novel anti-diabetic drugs. Furthermore, PTP1B inhibitor VIII has demonstrated inhibitory effects on the proliferation of cancer cells, positioning it as a promising candidate for the development of anti-cancer therapies. Ongoing research is exploring the pharmacological properties and potential medical applications of this compound.

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  • 1251533-99-9 Structure
  • Basic information

    1. Product Name: N-(4-chlorophenyl)-1-(pyriMidin-2-yl)-1H-pyrrole-2-sulfonaMide
    2. Synonyms: N-(4-chlorophenyl)-1-(pyriMidin-2-yl)-1H-pyrrole-2-sulfonaMide;N-(4-chlorophenyl)-1-(2-pyrimidinyl)-1H-Pyrrole-2-sulfonamide;N-(4-chlorophenyl)-1-pyrimidin-2-ylpyrrole-2-sulfonamide
    3. CAS NO:1251533-99-9
    4. Molecular Formula: C14H11ClN4O2S
    5. Molecular Weight: 334.78074
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1251533-99-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(4-chlorophenyl)-1-(pyriMidin-2-yl)-1H-pyrrole-2-sulfonaMide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(4-chlorophenyl)-1-(pyriMidin-2-yl)-1H-pyrrole-2-sulfonaMide(1251533-99-9)
    11. EPA Substance Registry System: N-(4-chlorophenyl)-1-(pyriMidin-2-yl)-1H-pyrrole-2-sulfonaMide(1251533-99-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1251533-99-9(Hazardous Substances Data)

1251533-99-9 Usage

Uses

Used in Pharmaceutical Industry:
N-(4-chlorophenyl)-1-(pyrimidin-2-yl)-1H-pyrrole-2-sulfonamide is used as a potential therapeutic agent for the treatment of various diseases, such as cancer and diabetes. Its ability to inhibit the activity of protein tyrosine phosphatase 1B (PTP1B) makes it a candidate for the development of novel anti-diabetic drugs.
Used in Cancer Research:
In the field of cancer research, N-(4-chlorophenyl)-1-(pyrimidin-2-yl)-1H-pyrrole-2-sulfonamide is used as an inhibitor of cancer cell proliferation. Its potential to impede the growth of cancer cells positions it as a promising candidate for the development of anti-cancer therapies.
Used in Diabetes Research:
N-(4-chlorophenyl)-1-(pyrimidin-2-yl)-1H-pyrrole-2-sulfonamide is also used in diabetes research as an inhibitor of PTP1B, an enzyme that plays a role in insulin and leptin signaling. Its potential to regulate these pathways makes it a candidate for the development of novel treatments for diabetes.

Check Digit Verification of cas no

The CAS Registry Mumber 1251533-99-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,1,5,3 and 3 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1251533-99:
(9*1)+(8*2)+(7*5)+(6*1)+(5*5)+(4*3)+(3*3)+(2*9)+(1*9)=139
139 % 10 = 9
So 1251533-99-9 is a valid CAS Registry Number.

1251533-99-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(4-chlorophenyl)-1-pyrimidin-2-yl-pyrrole-2-sulfonamide

1.2 Other means of identification

Product number -
Other names N-(4-chlorophenyl)-1-(pyrimidin-2-yl)-1H-pyrrole-2-sulfonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:1251533-99-9 SDS

1251533-99-9Upstream product

1251533-99-9Downstream Products

1251533-99-9Relevant articles and documents

THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE

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Page/Page column 108, (2010/11/03)

Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

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