- Backbone-extended pyrrolidine peptide nucleic acids (bepPNA): Design, synthesis and DNA/RNA binding studies
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One-carbon extended conformationally constrained pyrrolidine PNA monomer (bepPNA) has been synthesized, incorporated into PNA sequences at predefined positions, and showed selective RNA binding properties.
- Govindaraju,Kumar, Vaijayanti A.
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- Apoptotic protein inhibitor as well as preparation method and application thereof
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The invention relates to a compound with a structure as shown in a formula I which is described in the specification, a racemate, a stereoisomer, a tautomer, an isotope marker, a nitrogen oxide, a solvate, a polymorph, a metabolite, an ester, a prodrug or
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Paragraph 0266-0268
(2021/03/23)
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- Backbone extended pyrrolidine PNA (bepPNA): A chiral PNA for selective RNA recognition
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Synthesis of cationic, chiral PNA analogues with an extra atom in the backbone (bepPNA) is reported. The (2S,4S) geometry of the pyrrolidine ring, and an additional carbon atom in the backbone of homopyrimidine-bepPNAs resulted in the optimization of the inter-nucleobase distance, such that selective binding to complementary RNA over DNA was observed in the triplex mode. It was evident from circular dichroism studies that oligomers with mixed aminoethylglycyl-bep (aeg-bep) repeating units, and also bepPNA with homogeneous backbone attained structures quite different from those of aegPNA2:RNA/DNA complexes. The bepPNA, when incorporated in a duplex forming mixed purine-pyrimidine sequence, also showed a preference for binding complementary RNA over DNA.
- Govindaraju,Kumar, Vaijayanti A.
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p. 2321 - 2330
(2007/10/03)
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- Synthesis of trans-L/D-2-(tert-butoxycarbonylaminomethyl)-4-(thymin-1-yl) pyrrolidin-1-yl acetic acid
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To delineate the binding preferences of stereochemically divergent pyrrolidine PNAs, synthesis of all four diastreomeric monomers of I and the systematic complexation studies of the resultant PNAs with complementary DNA/ RNA is essential. We herein report the synthesis of trans-L/D-2-(tert-butoxycarbonylaminomethyl)-4-(thymin-1-yl) pyrrolidin-1-yl acetic acids I, their incorporation in PNA oligomers and DNA binding studies will be presented.
- Kumar, Vaijayanti A.,Meena
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p. 1285 - 1288
(2007/10/03)
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