- Reversible inhibitors of the gastric (H+/K+)-ATPase. 4. Identification of an inhibitor with an intermediate duration of action
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3-Acyl-4-(arylamino)quinolines were previously identified as gastric (H+/K+)-ATPase inhibitors, and clinical efficacy has been demonstrated for compound 3 (SK and F 96067). In the present study the further structure- activity relatio
- Leach,Brown,Ife,Keeling,Parsons,Theobald,Wiggall
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p. 2748 - 2762
(2007/10/03)
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- Compounds substituted quinoline derivatives
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Substituted 4-aminoquinazoline derivatives which are inhibitors of gastric acid secretion. A compound of the invention are the salts of strong acids of 3-butyryl-4-(2-methylphenylamino)-8-(hydroxymethyl)quinoline.
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- Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibitors
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Substituted 4-aminoquinazoline derivatives of the formula: STR1 in which R1 is hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxyC1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkylC1-6 alkyl, phenylC1-6 alkyl, the phenyl group being optionally substituted; R2 is hydrogen, C1-6 alkyl, C1-6 alkoxy, amino, C1-6 alkylthio, halogen, cyano, hydroxy, carbamoyl, carboxy, C1-6 alkanoyl or trifluoromethyl; m is 1 to 3; p is 0 to 4; R3 is COR4 ; R4 is hydroxy, C1-6 alkoxy, or NR5 R6 ; R5 and R6 are each hydrogen or C1-6 alkyl or together with the nitrogen atom to which they are attached form a heterocyclic ring; and R7 is hydrogen, C1-6 alkoxy or C1-6 alkyl; or a salt thereof.
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