- Enantioselective synthesis of anti-β-hydroxy-α-amido esters by asymmetric transfer hydrogenation in emulsions
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Herein, we present two methods for an asymmetric transfer hydrogenation through the dynamic kinetic resolution of α-amido-β-ketoesters. These procedures yield the corresponding anti-β-hydroxy-α-amido esters in good yields and with good diastereo- and enantioselectivities. First, the scope of the reduction of α-amido-β-ketoesters by using triethylammonium formate azeotrope is examined. Then, an emulsion technology with sodium formate is explored, which allows for broader substrate scope, faster reaction times, and lower catalyst loading. Furthermore, these reactions are operationally simple and can be set up in air.
- Seashore-Ludlow, Brinton,Villo, Piret,Somfai, Peter
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supporting information; experimental part
p. 7219 - 7223
(2012/07/13)
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- Enantioselective synthesis of anti -β-hydroxy-α-amido esters via transfer hydrogenation
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The asymmetric transfer hydrogenation of α-amido-β-keto esters to provide the corresponding anti-β-hydroxy-α-amido esters in good to excellent yields, diastereoselectivity, and enantioselectivity is reported. The procedure is operationally simple, and delicate handling of the catalyst is not necessary.
- Seashore-Ludlow, Brinton,Villo, Piret,Haecker, Christine,Somfai, Peter
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supporting information; experimental part
p. 5274 - 5277
(2011/01/12)
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