- Polyfunctional phosphine ligands. Preparation of 4'-formyl-2-diphenylphosphinoacetophenone and its coordination properties
-
The trifunctional ligand C(O)CH2PPh2 (5) has been prepared in four steps (overall yield 50percent) starting from terephthalaldehyde mono-(diethylacetal) (1): reaction of 1 with CH3MgBr gives C6H4>CH(OH)CH3 (2).This is oxidize
- Soulivong, Daravong,Ziessel, Raymond,Matt, Dominique
-
p. 207 - 216
(2007/10/02)
-
- Synthesis and coordination properties of novel polyfunctional phosphine ligands
-
4′-formyl-2-diphenylphosphino-acetophenone 5 has been prepared in four steps (50%) starting from terephtalaldehyde mono-(diethylacetal) 1. Condensation of 5 with the para-substituted anilines H2NA-i gives quantitatively the phosphine-imines 6-8
- Soulivong, Daravong,Matt, Dominique,Ziessel, Raymond,Douce, Laurent,Deschenaux, Robert
-
p. 1151 - 1154
(2007/10/02)
-
- Novel Thiazolidine-2,4-diones as Potent Euglycemic Agents
-
A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety.These compounds lower blood glucose levels in the genetically obese and insulin-r
- Hulin, Bernard,Clark, David A.,Goldstein, Steven W.,McDermott, Ruth E.,Dambek, Paul J.,et al.
-
p. 1853 - 1864
(2007/10/02)
-
- Hypoglycemic thiazolidinedione derivatives
-
Hypoglycemic thiazolidine-2,4-derivatives STR1 wherein the dotted line represents a bond or no bond; V is --CH=CH--, --N=CH--, --CH=N-- or S; W is CH2, CHOH, CO, C=NOR or --CH=CH--; X is S, O, NR1, --CH=N-- or --N=CH--; Y is CH or N; Z is hydrogen, (C1 -C7)alkyl, (C3 -C7)cycloalkyl, phenyl, naphtyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C1 -C3)alkyl, trifluoromethyl, (C1 -C3)alkoxy, fluoro, chloro or bromo; Z1 is hydrogen or (C1 -C3)alkyl; R is hydrogen or methyl; and n is 1, 2 or 3; a pharamceutically acceptable cationic salt thereof; or a pharmaceutically acceptable acid addition salt thereof when the compound contains basic nitrogen.
- -
-
-
- Hypoglycemic thiazolidinedione derivatives
-
Hypoglycemic thiazolidine-2,4-dione derivatives wherein the dotted line represents a bond or no bond;, V is -CH=CH-, -N=CH-, -CH=N- or S;, W is CH2, CHOH, CO, C=NOR or -CH=CH-;, X is S, O, NR1, -CH=N- or -N=CH-;, Y is CH or N;, Z is hydrogen, (C1-C7)alkyl, (C3-C7)cycloalkyl, phenyl, naphthyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C1-C3)alkyl, trifluoromethyl, (C1-C3)alkoxy, fluoro, chloro or bromo;, Z1 is hydrogen or (C1-C3)alkyl;, R is hydrogen or methyl; and, n is 1, 2 or 3;, a pharmaceutically acceptable cationic salt thereof; or a pharmaceutically acceptable acid addition salt thereof when the compound contains a basic nitrogen.
- -
-
-