A synthetic strategy toward eight-membered cyclic amines by cycloetherification and claisen rearrangement
Eight-membered nitrogen-containing heterocycles were straightforwardly produced by a nickel-catalyzed cycloetherification and subsequent Claisen rearrangement of secondary and tertiary alcohols. In particular, a one-pot transformation was achieved with tertiary alcohols in moderate to good yields. This operationally simple reaction is tolerant of many functional groups and applicable to the synthesis of various medium-sized ring nitrogen-containing heterocycles.
Han, Seo-Jung,Cavitt, Marchello A.,Stoltz, Brian M.
Dynamic kinetic asymmetric cycloadditions of isocyanates to vinylaziridines
The first examples of the use of racemic vinylaziridines in a Pd-catalyzed dynamic kinetic asymmetric transformation have been examined. Optimization studies of the Pd-catalyzed addition of vinylaziridines to isocyanates revealed that the chiral ligand be
Trost, Barry M.,Fandrick, Daniel R.
p. 11836 - 11837
(2007/10/03)
AMINOLEAD COMPOUNDS AS A NEW REAGENT FOR REGIOSELECTIVE RING OPENING OF EPOXIDES
Regioselective ring opening of epoxides is accomplished by using aminolead compounds; the reagents attack the less hindered carbon of epoxide ring, and the amino alcohols are obtained in good yields.