- Enantioselective additions of (trifluoromethyl)trimethylsilane to α-imino ketones derived from aryl glyoxals
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Chemoselective additions of (trifluoromethyl)trimethylsilane to α-imino ketones derived from aryl glyoxals in the presence of a catalytic amount of enantiomerically pure ammonium bromides, derived from Cinchona alkaloids and K2CO3 le
- Obijalska, Emilia,Mlostoń, Grzegorz,Six, Alice
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p. 2462 - 2465
(2013/07/05)
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- Asymmetric synthesis of β-amino alcohols by the transfer hydrogenation of α-keto imines
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The asymmetric transfer hydrogenation of representative aryl and benzofuranyl 2-tert-butylaminoethanones with formic acid-triethylamine, catalyzed by RhCl[(R,R)-TsDPEN](C5Me5), produced the corresponding β-tert-butylamino alcohols in 97-99% ee. A short asymmetric synthesis of (R)-bufuralol, a potent β-adrenergic receptor antagonist, is described. This approach to β-amino alcohols from ketones circumvents the halogenation-reduction-amination sequence.
- Tafelska-Kaczmarek, Agnieszka,Prewysz-Kwinto, Andrzej,Skowerski, Krzysztof,Pietrasiak, Katarzyna,Kozakiewicz, Anna,Zaidlewicz, Marek
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scheme or table
p. 2244 - 2248
(2010/11/03)
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- Reactions of α-imino ketones derived from arylglyoxals with (trifluoromethyl)trimethylsilane; A new route to β-amino-α- trifluoromethyl alcohols
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The reactions of α-imino ketones, derived from arylglyoxals, with (trifluoromethyl)trimethylsilane (CF3SiMe3) in DME solution, in the presence of catalytic amount of CsF, at room temperature, yield O-silylated β-imino alcohols in the
- Mloston, Grzegorz,Obijalska, Emilia,Tafelska-Kaczmarek, Agnieszka,Zaidlewicz, Marek
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experimental part
p. 1289 - 1296
(2011/02/22)
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