Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): Isoxazoline zinc amidase inhibitors bearing diverse metal binding groups
UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase (LpxC) is a zinc amidase that catalyzes the second step of lipid A biosynthesis in Gram negative bacteria. Known inhibitors of this enzyme are oxazolines incorporating a hydroxamic acid at the 4-position,
Pirrung, Michael C.,Tumey, L. Nathan,Raetz, Christian R. H.,Jackman, Jane E.,Snehalatha, Karnem,McClerren, Amanda L.,Fierke, Carol A.,Gantt, Stephanie L.,Rusche, Kristin M.
p. 4359 - 4370
(2007/10/03)
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