1256781-73-3

Basic information

• Product Name: 2-Chloro-5-Methoxyphenylboronic acid pinacol ester
• Synonyms: 2-Chloro-5-Methoxyphenylboronic acid pinacol ester;2-(2-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS NO: 1256781-73-3
• Molecular Formula: C₁₃H₁₈BClO₃
• Molecular Weight: 268.54422
• Mol File: 1256781-73-3.mol

Chemical Properties

• Boiling Point: 358.8±32.0 °C(Predicted)
• Appearance: /
• Density: 1.12±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Chloro-5-Methoxyphenylboronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-Methoxyphenylboronic acid pinacol ester(1256781-73-3)
• EPA Substance Registry System: 2-Chloro-5-Methoxyphenylboronic acid pinacol ester(1256781-73-3)

Safety Data

• Hazardous Substances Data: 1256781-73-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-5-Methoxyphenylboronic acid pinacol ester is used as a reagent in the synthesis of pharmaceuticals for its ability to form carbon-carbon and carbon-heteroatom bonds. Its stability and reactivity make it suitable for creating complex molecular structures required in drug development.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Chloro-5-Methoxyphenylboronic acid pinacol ester is used as a reagent for the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural compounds that require specific carbon-carbon and carbon-heteroatom bond formations.
Used in Materials Science:
2-Chloro-5-Methoxyphenylboronic acid pinacol ester is utilized as a reagent in the synthesis of advanced materials, where its ability to form specific bonds is crucial for creating new materials with desired properties.
Used as an Intermediate in Organic Synthesis:
2-Chloro-5-Methoxyphenylboronic acid pinacol ester also serves as an intermediate in the production of other complex organic compounds, further expanding its applications across various chemical and industrial processes.

Upstream product

• 325142-84-5 3-methoxyphenylboronic acid pinacol ester 
• 623-12-1 4-chloromethoxybenzene 
• 73183-34-3 bis(pinacol)diborane 
• 128-09-6 N-chloro-succinimide 

Relevant articles and documents

Metal-free halogenation of arylboronate with N-halosuccinimide

Efficient bromination and chlorination of aryl pinacol boronates were accomplished without the addition of metal reagent. The reaction proceeded efficiently with electron-rich arylboronates or heteroarylboronates in DMF or acetonitrile, to afford mono-, di-, or trihalogenated aryl pinacol boronates.

Metal-free halogenation of arylboronate with N-halosuccinimide

Efficient bromination and chlorination of aryl pinacol boronates were accomplished without the addition of metal reagent. The reaction proceeded efficiently with electron-rich arylboronates or heteroarylboronates in DMF or acetonitrile, to afford mono-, d

Rhodium-catalyzed intermolecular C-H silylation of arenes with high steric regiocontrol

Regioselective C-H functionalization of arenes has widespread applications in synthetic chemistry. The regioselectivity of these reactions is often controlled by directing groups or steric hindrance ortho to a potential reaction site. Here, we report a catalytic intermolecular C-H silylation of unactivated arenes that manifests very high regioselectivity through steric effects of substituents meta to a potential site of reactivity. The silyl moiety can be further functionalized under mild conditions but is also inert toward many common organic transformations, rendering the silylarene products useful building blocks. The remote steric effect that we observe results from the steric properties of both the rhodium catalyst and the silane.

Gold(iii)-catalyzed halogenation of aromatic boronates with N -halosuccinimides

Aromatic boronates bearing halogen substituents in the aromatic ring can be synthesized by AuCl3-catalyzed halogenations with N-halosuccinimides.