A one-pot synthesis of 2-chloronicotinonitriles and fused 2-chloro-3-cyanopyridines
2-Chloronicotinonitriles (2a-d) and fused bi- and tricyclo-2-chloro-3-cyanopyridines (2e-h) are obtained from alkylidenemalononitriles (1a-h) by Vilsmeier reaction.Generation in situ of an aldehyde equivalent species in the Vilsmeier reaction at the γ-carbon with respect to the nitrile carbon of the alkylidenemalononitriles, followed by cylization, both occurring in one-pot, are presumed to be involved in the pyridoannulation.
Sreenivasulu, M.,Rao, G. S. Krishna
p. 584 - 586
(2007/10/02)
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