1257598-91-6

Basic information

• Product Name: (E)-methyl 3-methoxy-2-(2-(((2-(phenylamino)-5,6,7,8-tetrahydroquinazolin-4-yl)oxy)methyl)phenyl)acrylate
• Synonyms: (E)-methyl 3-methoxy-2-(2-(((2-(phenylamino)-5,6,7,8-tetrahydroquinazolin-4-yl)oxy)methyl)phenyl)acrylate
• CAS NO: 1257598-91-6
• Molecular Weight: 445.518
• Mol File: 1257598-91-6.mol

Chemical Properties

• CAS DataBase Reference: (E)-methyl 3-methoxy-2-(2-(((2-(phenylamino)-5,6,7,8-tetrahydroquinazolin-4-yl)oxy)methyl)phenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-methyl 3-methoxy-2-(2-(((2-(phenylamino)-5,6,7,8-tetrahydroquinazolin-4-yl)oxy)methyl)phenyl)acrylate(1257598-91-6)
• EPA Substance Registry System: (E)-methyl 3-methoxy-2-(2-(((2-(phenylamino)-5,6,7,8-tetrahydroquinazolin-4-yl)oxy)methyl)phenyl)acrylate(1257598-91-6)

Safety Data

• Hazardous Substances Data: 1257598-91-6(Hazardous Substances Data)

Upstream product

• 117428-51-0 methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate 
• 97041-36-6 C₁₄H₁₅N₃O 
• 62-53-3 aniline 

Relevant articles and documents

Synthesis of novel strobilurin-pyrimidine derivatives and their antiproliferative activity against human cancer cell lines

A series of new strobilurin-pyrimidine analogs were designed and synthesized based on the structures of our previously discovered antiproliferative compounds I and II. Biological evaluation with two human cancer cell lines (A549 and HL60) showed that most of these compounds possessed moderate to potent antiproliferative activity. Two potent candidates (8f, IC50 = 2.2 nM and 11d, IC50 = 3.4 nM) were identified with nanomolar activity against leukemia cancer cell line HL60 for further development. This activity represents a 1000- to 2500-fold improvement compared to the parent compounds I and II and is 20- to 30-fold better than the chemotherapy drug, doxorubicin. The present work provides strong incentive for further development of these strobilurin-pyrimidine analogs as potential antitumor agents for the treatment of leukemia.