- Five-membered heterocycle substituted biphenyl compound and preparation method and application thereof
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The invention discloses an immune checkpoint inhibitor five-membered heterocycle substituted biphenyl compound capable of blocking a PD-1/PD-L1 signal pathway and a preparation method and application thereof. The compound is shown in the formula I as described in the specification. The compound is novel in structure and can be orally taken, the defects of treatment and drug resistance of a monoclonal antibody immune checkpoint inhibitor are overcome, and as a small-molecule inhibitor, the preparation is simple, and industrial production is convenient; various related tumor diseases can be treated through tumor immunotherapy by regulating and controlling a PD-1/PD-L1 signal pathway, and potential patent medicine prospects are achieved.
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Paragraph 0184; 0186-0189
(2021/07/17)
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- BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS
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Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).
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Page/Page column 194
(2016/11/17)
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- 5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS
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5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.
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Page/Page column 26
(2011/01/12)
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