- INDOLE-OXADIAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE
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The present application pertains to methods of using indole-oxadiazole compounds of Formula I to modulate cannabinoid receptor activity: I In particular diseases, disorders or conditions that benefit from modulating cannabinoid receptor activity, such as non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), schizophrenia, bipolar disorder, psychosis, metabolic syndrome, type-2 diabetes, dyslipidaemia, obesity, eating disorders, cardiovascular diseases and disorders, and other conditions as described herein, may be treated. Also included in the present application are certain novel compounds of Formula Ia and pharmaceutical compositions comprising these compounds.
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Paragraph 00185; 00190-00191
(2020/05/07)
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- Synthesis of oxadiazolyl-, thiadiazolyl- and triazolylindoles and indolylthiazolidinones
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Ethyl substituted indole-2-carboxylates (1a-n) are reacted with hydrazine hydrate to get the corresponding carbohydrazides (2a-n).These hydrazides are condensed with phenyl isothiocyanate to get 1-phenyl-3-(substituted indole-2'-carboxamido)thioureas (3a-
- Hiremath, S. P.,Sonar, V. N.,Raja Sekhar, K.,Purohit, M. G.
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p. 626 - 630
(2007/10/02)
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