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1260251-31-7

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Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate
Birinapant/TL32711 (1) is a novel bivalent antagonist of the inhibitor of apoptosis (IAP) family of proteins which is currently in clinical development for the treatment of cancer and hepatitis B virus (HBV) infection. In this report, we present a detaile
Deng, Yijun,Xie, Qiuzhe,LaPorte, Matthew G.,Chasnoff, Anna T. A.,Mortensen, Mark A.,Patra, Debasis,Putrelo, Seth A.,Antonovich, Robert S.,Cao, Hong,Yan, Jun,Cooper, Arthur J.,Rippin, Susan R.,Alexander, Matthew D.,Kumar, Pavan Tirunahari,Hendi, Mukta S.,Lee, Yu-Hua,Haimowitz, Thomas,Condon, Stephen M.
p. 242 - 252
(2016/03/04)

SMAC MIMETIC (BIRINAPANT) FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES (CANCER)
A method of using a Smac mimetic and pharmaceutical compositions thereof.
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Paragraph 0074; 0075; 0076

(2013/04/13)

SMAC Mimetic
A SMAC mimetic and pharmaceutical compositions thereof and methods of use.
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Page/Page column 15

(2011/01/12)

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Chemical Properties

Melting Point: >245oC (dec.)
Boiling Point: 1090.5±65.0 °C(Predicted)
Density: 1.320±0.06(20.0000℃)
Solubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Storage Temp.:-20°C Freezer
PKA: 13.99±0.46(Predicted)

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