Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor
A flow method for the synthesis of aliphatic and aromatic diazoketones from acyl chloride precursors has been developed and used to prepare quinoxalines in a multistep sequence without isolation of the potentially explosive diazoketone. The protocol showcases an efficient in-line purification using supported scavengers with time-saving and safety benefits and in particular a reduction in the operator's exposure to carcinogenic phenylenediamines.
Martin, Laetitia J.,Marzinzik, Andreas L.,Ley, Steven V.,Baxendale, Ian R.
p. 320 - 323
(2011/03/23)
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