Total synthesis, stereochemical assignment, and biological activity of chamuvarinin and structural analogues
A highly stereocontrolled synthesis of (+)-chamuvarinin has been completed in 1.5 % overall yield over 20 steps. The key fragment coupling reactions were the addition of alkyne 8 to aldehyde 7 (under Felkin-Anh control), followed by the two step activatio
Florence, Gordon J.,Morris, Joanne C.,Murray, Ross G.,Vanga, Raghava R.,Osler, Jonathan D.,Smith, Terry K.
p. 8309 - 8320
(2013/07/27)
Synthesis and stereochemical assignment of (+)-chamuvarinin
A stereocontrolled total synthesis of (+)-chamuvarinin, isolated from the root extract of Uvaria Chamae, utilizes a convergent modular strategy to construct the adjacently linked C15-C28 ether array, followed by a late-stage Julia-Kocienski olefination to
Florence, Gordon J.,Morris, Joanne C.,Murray, Ross G.,Osler, Jonathan D.,Reddy, Vanga R.,Smith, Terry K.
supporting information; experimental part
p. 514 - 517
(2011/04/17)
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