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1261629-96-2

Ethyl 4-hydroxyquinoline-7-carboxylate, commonly known as chloroquine, is a synthetic aryl aminoquinoline derivative characterized by its antimalarial and immunosuppressive properties. It functions by inhibiting heme polymerase, thereby preventing the polymerization of heme, a toxic byproduct of hemoglobin breakdown. This mechanism is crucial in combating the malarial parasite, which is vulnerable to the toxic effects of heme. In autoimmune disorders, chloroquine is believed to reduce the immune response, and it also exhibits anti-inflammatory properties, potentially inhibiting the production and release of tumor necrosis factor-alpha and interleukin-6. However, the use of chloroquine must be carefully managed due to its associated adverse effects, which can range from mild gastrointestinal discomfort to severe retinal toxicity and cardiac arrhythmias.

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  • 1261629-96-2 Structure

  • Basic information

    1. Product Name: Ethyl 4-hydroxyquinoline-7-carboxylate
    2. Synonyms: Ethyl 4-hydroxyquinoline-7-carboxylate
    3. CAS NO:1261629-96-2
    4. Molecular Formula: C12H11NO3
    5. Molecular Weight: 217.22064
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1261629-96-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: Ethyl 4-hydroxyquinoline-7-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: Ethyl 4-hydroxyquinoline-7-carboxylate(1261629-96-2)
    11. EPA Substance Registry System: Ethyl 4-hydroxyquinoline-7-carboxylate(1261629-96-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1261629-96-2(Hazardous Substances Data)

1261629-96-2 Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 4-hydroxyquinoline-7-carboxylate is used as an antimalarial agent for treating malaria caused by Plasmodium species. It is effective due to its ability to inhibit heme polymerase, which is crucial for the survival of the malarial parasite.
Used in Autoimmune Disorders:
Ethyl 4-hydroxyquinoline-7-carboxylate is used as an immunosuppressive agent for managing autoimmune disorders. It is believed to dampen the immune response, providing relief from symptoms associated with these conditions.
Used in Anti-inflammatory Applications:
Ethyl 4-hydroxyquinoline-7-carboxylate is used as an anti-inflammatory agent, potentially inhibiting the production and release of pro-inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6, which play a role in the inflammatory response.
Used in Research:
Ethyl 4-hydroxyquinoline-7-carboxylate is used as a research tool in studying the mechanisms of action of antimalarial drugs, as well as in investigating the role of heme polymerase in various diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 1261629-96-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,1,6,2 and 9 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1261629-96:
(9*1)+(8*2)+(7*6)+(6*1)+(5*6)+(4*2)+(3*9)+(2*9)+(1*6)=162
162 % 10 = 2
So 1261629-96-2 is a valid CAS Registry Number.

1261629-96-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 4-hydroxyquinoline-7-carboxylate

1.2 Other means of identification

Product number -
Other names ethyl 4-oxo-1H-quinoline-7-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1261629-96-2 SDS

1261629-96-2Downstream Products

1261629-96-2Relevant articles and documents

PRMT5 INHIBITORS

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Page/Page column 79-80, (2021/06/26)

The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

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