126216-46-4Relevant articles and documents
Amination with N-Benzyloxycarbonyl-3-Phenyloxaziridine as a Route to Sensitive Chiral α-Hydrazino Acids: Synthesis of L-Hydrazino Serine
Niederer, Daniel A.,Kapron, James T.,Vederas, John C.
, p. 6859 - 6862 (2007/10/02)
N-Cbz-3-phenyloxaziridine can be generated in a two step process.This is a new reagent for direct electrophilic N-amination of chiral α-amino acids and their derivatives which affords the corresponding hydrazino acids protected with a readily removable N-Cbz group.Application of this methodology to a facile synthesis of L-hydrazino serine, a potentially useful biological tool, is described.
A Novel and Versatile Synthesis of 1-Alkyl-, 1-Aryl-, 1-(Alkylamino)-, or 1-Amido-Substituted and of 1,2,6-Trisubstituted Piperidines from Glutaraldehyde and Primary Amines or Monosubstituted Hydrazines
Katritzky, Alan R.,Fan, Wei-Qiang
, p. 3205 - 3209 (2007/10/02)
Various primary amines and 1-mono- and 1,1-disubstituted hydrazines were converted into the corresponding N-substituted piperidines in good to excellent yields via the products of double condensations with benzotriazole and glutaraldehyde.Reduction of the 2,6-bis(benzotriazolyl) N-substituted piperidines 4 and 7 with sodium borohydride in tetrahydrofuran afforded N-substituted piperidines.The benzotriazole moieties were also replaced by alkyl groups by reaction with Grignard reagents to produce 1,2,6-trisubstituted piperidines.
