Quinine-catalysed double Michael addition of malononitrile to 1,5-disubstituted pentadien-3-ones: A stereoselective route to cyclohexanones
The stereoselective synthesis of 4-oxo-2,6-diaryl-cyclohexane-1,1- dicarbonitriles has been developed through double Michael addition of malononitrile to 1,5-disubstituted pentadien-3-ones catalysed by quinine. This simple cascade process affords cyclohex
De Fusco, Claudia,Lattanzi, Alessandra
supporting information; experimental part
p. 3728 - 3731
(2011/09/16)
Asymmetric organocatalytic double-conjugate addition of malononitrile to dienones: Efficient synthesis of optically active cyclohexanones
9-Amino-9-deoxyepiquinine efficiently catalyzed the double-conjugate addition of malononitrile to dienones. A number of 1,1,2,6-tetrasubstituted cyclohexanones were prepared in good yields, diastereoselectivities, and excellent enantioselectivities.
Li, Xue-Ming,Wang, Bo,Zhang, Jun-Min,Yan, Ming
scheme or table
p. 374 - 377
(2011/04/15)
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