- NITROGENOUS FUSED HETEROAROMATIC RING DERIVATIVE
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The invention provides a compound or its pharmaceutically-acceptable salt of formula (I): wherein A1 is a hydrogen, etc.; j and k are 0 or 1; is a double bond, etc.; is a double bond, etc.; one of W1 and W2 is E-O-W, etc., and the other is a hydrogen atom, etc.; E is a divalent group derived from a benzene ring, etc., by removing two hydrogen atoms therefrom; W is a group of formula (II-1): which has a histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect and is useful for prevention or remedy of metabolic system diseases, circulatory system diseases or nervous system diseases.
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Page/Page column 49
(2010/11/24)
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- Synthesis and biological activity of 3,6-diaryl-1,2,4-triazolo-phthalazines
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4-(4'-Chlorophenyl)-1-hydrazinophthalazine (1) and 4-(4'-methoxyphenyl)-1-hydrazinophthalazine (2) condense with aromatic aldehydes (3) to give 4-(4'-chlorophenyl)-1-benzalhydrazinonaphthalazines (4) and 4-(4'-methoxyphenyl)-1-benzalhydrazinonaphthalazine
- Razvi,Ramalingam,Sattur
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p. 987 - 989
(2007/10/02)
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