Welcome to LookChem.com Sign In|Join Free

CAS

  • or
1262523-70-5 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1262523-70-5 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • L- Glutamine, N2- [(1, 1- dimethylethoxy) carbonyl] - 4- fluoro- N- [(2, 4, 6- trimethoxyphenyl) methyl] - , 1, 1- dimethylethyl ester, (4R) -

    Cas No: 1262523-70-5

  • USD $ 1.9-2.9 / Gram

  • 100 Gram

  • 1000 Metric Ton/Month

  • Chemlyte Solutions
  • Contact Supplier
  • 1262523-70-5 Structure
  • Basic information

    1. Product Name: 1262523-70-5
    2. Synonyms: L-Glutamine, N2-[(1,1-dimethylethoxy)carbonyl]-4-fluoro-N-[(2,4,6-trimethoxyphenyl)methyl]-, 1,1-dimethylethyl ester, (4R)-
    3. CAS NO:1262523-70-5
    4. Molecular Formula: C24H37FN2O8
    5. Molecular Weight: 500.5575832
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 1262523-70-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1262523-70-5(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1262523-70-5(1262523-70-5)
    11. EPA Substance Registry System: 1262523-70-5(1262523-70-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1262523-70-5(Hazardous Substances Data)

1262523-70-5 Usage

Chemical compound

1262523-70-5

Type

Synthetic organic compound

Function

Potent and selective inhibitor of the PARP enzyme

Involvement

DNA repair and maintenance

Therapeutic applications

Being studied for potential use in cancer treatment

Preclinical studies

Shown promising results

Research focus

Enhancing efficacy of traditional cancer treatments (chemotherapy and radiotherapy)

Potential implications

Other disease areas, such as neurodegenerative disorders and inflammatory diseases

Further research

Clinical trials and additional studies needed to understand full potential as a therapeutic agent.

Check Digit Verification of cas no

The CAS Registry Mumber 1262523-70-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,2,5,2 and 3 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1262523-70:
(9*1)+(8*2)+(7*6)+(6*2)+(5*5)+(4*2)+(3*3)+(2*7)+(1*0)=135
135 % 10 = 5
So 1262523-70-5 is a valid CAS Registry Number.

1262523-70-5Downstream Products

1262523-70-5Relevant articles and documents

Synthesis of optically pure 4-fluoro-glutamines as potential metabolic imaging agents for tumors

Qu, Wenchao,Zha, Zhihao,Ploessl, Karl,Lieberman, Brian P.,Zhu, Lin,Wise, David R.,Thompson, Craig B.,Kung, Hank F.

, p. 1122 - 1133 (2011/04/16)

A versatile synthetic route to prepare all four stereoisomeric 4-fluoro-glutamines was developed by exploiting a Passerini three-component reaction. The skeleton of 4-substituted glutamine derivatives was efficiently constructed. Subsequent four-step reactions, highlighted by a "neutralized" TASF fluorination, provided the desired products with high yields and excellent optical purity. The optically pure fluorine-18 labeled 4-fluoroglutamines were also successfully prepared using either a 18-crown-6/KHCO3 or K[222]/K2CO3 catalysis system. Preliminary cell uptake and inhibition studies using the 9L tumor cells ana SF188BC1-XL tumor cells (a glutamine addicted tumor derived from glioblastoma) provided strong evidence for their potential application in conjunction with positron emission tomography (PET) for in vivo imaging of tumors, which use glutamine as an alternative energy source.

SINGLE DIASTEREOMERS OF 4-FLUOROGLUTAMINE AND METHODS FO THEIR PREPARATION AND USE

-

Page/Page column 29-30, (2011/02/24)

The present invention is directed single diasteromers of 4-fluoroglutamine having a diastereomeric excess of at least 80%. Methods of preparing the single diastereomers are also described, as well as methods of using the single diastereomers of radiolabeled 4-fluoroglutamine as imaging agent is also described.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1262523-70-5