cas 1262618-39-2, GS967 | Articles data

The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

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1262618-39-2

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Chemical Properties

Density: 1.52±0.1 g/cm3(Predicted)

Solubility:insoluble in H2O; ≥13.35 mg/mL in DMSO; ≥25.52 mg/mL in EtOH with ultrasonic

PKA: -0.41±0.50(Predicted)

PSA: 39.42000

LogP: 4.31370

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