- A versatile new catalyst for the enantioselective isomerization of allylic alcohols to aldehydes: Scope and mechanistic studies
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A new planar-chiral bidentate phosphaferrocene ligand (2) has been synthesized and structurally characterized. The derived rhodium complex, [Rh(cod)(2)]BF4, serves as an effective catalyst for asymmetric isomerizations of allylic alcohols to aldehydes, furnishing improved yields, scope, and enantioselectivities relative to previously reported methods. The catalyst is air-stable and can be recovered at the end of the reaction. Mechanistic studies establish that the isomerization proceeds via an intramolecular 1,3-hydrogen migration and that the catalyst differentiates between the enantiotopic C1 hydrogens.
- Tanaka, Ken,Fu, Gregory C.
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p. 8177 - 8186
(2007/10/03)
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- 1,2-Secopyrethroids: Synthesis of (+/-) α-(RS)-cyano-3-phenoxybenzyl-4-methyl-3-phenyl/p-substituted-phenylpentanoates
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A simple, elegant synthesis of (+/-) α-(RS)-cyano-3-phenoxybenzyl-4-methyl-3-phenyl/p-substituted-phenylpentanoates (I,XIV,XXI) has been described.
- Kher, S. M.,Kulkarni, G. H.
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p. 675 - 676
(2007/10/02)
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