- A Mild Method for Access to α-Substituted Dithiomalonates through C-Thiocarbonylation of Thioester: Synthesis of Mesoionic Insecticides
-
An efficient method for targeting a variety of symmetrical and asymmetrical α-substituted dithiomalonates (DTMs) is described, utilizing 1H-imidazole-1-carbothioates as reactive acylating agents and MgBr2?OEt2/DBU or LiHMDS for soft or hard enolization conditions of thioesters, respectively. The utility of this methodology was demonstrated through the synthesis of the pyridopyrimidine mesoionic insecticides: triflumezopyrim and dicloromezotiaz. (Figure presented.).
- Di, Huiming,Jin, Hui,Ma, Yanrong,Ryu, Do Hyun,Wang, Xiaochen,Yang, Xinyue,Zhang, Lixin
-
p. 3201 - 3206
(2021/05/31)
-
- Preparation method of pemetrexed disodium
-
A preparation method of pemetrexed disodium is disclosed. The preparation method comprises the following steps: (1) dissolving 30-35 parts of 2-(3-(trifluoromethyl)phenyl) malonate and 15-20 parts ofN-(pyridin-5-yl methyl) pyridine-2-amine in a solvent, a
- -
-
Paragraph 0029-0052; 0060-0065
(2020/09/08)
-
- Mesoionic pyrido[1,2-a]pyrimidinones: Discovery of triflumezopyrim as a potent hopper insecticide1
-
A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species. In this communication, we report the part of the optimization program which led to the discovery of triflumezopyrim as a highly potent insecticide controlling various hopper species. Our efforts in discovery, synthesis, structure-activity relationship elucidation, and biological activity evaluation are also presented.
- Zhang, Wenming,Holyoke, Caleb W.,Pahutski, Thomas F.,Lahm, George P.,Barry, James D.,Cordova, Daniel,Leighty, Robert M.,Singh, Vineet,Vicent, Daniel R.,Tong, My-Hanh T.,Hughes, Kenneth A.,McCann, Stephen F.,Henry, Yewande T.,Xu, Ming,Briddell, Twyla A.
-
-
- MALONIC ACID DI-SALTS AND A METHOD FOR PREPARING MALONYL DIHALIDES
-
A compound of Formula (2) is disclosed: wherein R1, MA and MB are as defined in the disclosure. Also disclosed is a method for preparing a compound of Formula (1): wherein R1 and X are as defined in the disclosure comprising contacting a compound of Formula (2) with a halogenating agent. Also disclosed is a method for preparing a compound of Formula (4): wherein R1, R3 and R4 are as defined in the disclosure, comprising reacting a compound of Formula (5): wherein R3 and R4 are as defined in the disclosure with a compound of Formula (1), with a compound of Formula (1), the process of preparing the compound of Formula (4) includes the step of preparing the compound of Formula (1) from the compound of Formula (2) by the method disclosed above. Also disclosed is compound that is methyl 3,5-dichlorobenzeneethanimidate methyl 3,5 dichlorobenzeneethanimidate or ethyl 3,5 dichlorobenzeneethanimidate or salts thereof.
- -
-
-
- MESOIONIC PYRIDO [1,2 -A] PYRIMIDINE PESTICIDES
-
Disclosed are compounds of Formula 1, wherein R1? is phenyl or pyridinyl, each optionally substituted with Q and up to 3 substituents independently selected from R2; each R2 is independently halogen, cyano, SF5 C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio or C1-C4 haloalkylthio; and Q is phenyl or pyridinyl, each optionally substituted with up to 5 substituents independently selected from the group consisting of halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy and C1-C4 haloalkoxy. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention. Further disclosed are methods for increasing vigor of a crop plant comprising contacting the crop plant, the seed from which the crop plant is grown or the locus of the crop plant with a biologically effective amount of a compound or composition of the invention.
- -
-
-
- MIXTURES OF MESOIONIC PESTICIDES
-
Disclosed are compositions comprising (a) at least one compound selected from compounds of Formula (1), N-oxides, and salt thereof, wherein R1 is phenyl optionally substituted with up to 5 substituents independently selected from R3,
- -
-
Page/Page column 172
(2011/02/24)
-